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Vitamin K1

Catalog No. T1075   CAS 84-80-0
Synonyms: Phylloquinone, Phytomenadione, Phytonadione, Phyllohydroquinone

Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.

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Vitamin K1 Chemical Structure
Vitamin K1, CAS 84-80-0
Pack Size Availability Price/USD Quantity
1 g In stock $ 37.00
5 g In stock $ 97.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
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Purity: 99.82%
Purity: 99.53%
Purity: 98.11%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.
In vitro Phylloquinone (Vitamin K1) is a prenylated naphthoquinone that is synthesized exclusively by plants, green algae, and some species of cyanobacteria, where it serves as a vital electron carrier in photosystem I and as an electron acceptor for the formation of protein disulfide bonds. Phylloquinone plays the role of a vitamin (vitamin K1) that is required for blood coagulation and bone and vascular metabolism in humans and other vertebrates. Phylloquinone from green leafy vegetables and vegetable oil represents the major dietary source of vitamin K for humans[1]. Vitamin K1 treatment causes a significant antiproliferative effect and induces apoptosis in Caco-2, HT-29, and SW480 cell lines, with the involvement of the MAPK pathway. A concomitant and significant decrease in the polyamine biosynthesis occurr[2].
In vivo Subjects who increased their dietary intake of vitamin K during the follow-up had a 51% reduced risk of incident diabetes compared with subjects who decrease or does not change the amount of phylloquinone intake[3]. Vitamin K supplementation reverses the high fat diet induced bone deterioration by modulating osteoblast and osteoclast activities and prevent bone loss in a high-fat diet-induced obese mice[4]. Application of vitamin K1 to the skin has been used for suppression of pigmentation and resolution of bruising. The effects produced by the topical vitamin K1 exhibit significant healing when compared with control group in parameters like wound contraction, epithelialization period, hydroxyproline content and tensile strength[5].
Cell Research Caco-2, HT-29, and SW480 cells are treated with increasing concentrations of vitamin K1 (10, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h. MTT is added to each dish and incubated for 2 h at 37°C. At the end of the incubation period, the medium is removed. The plate is read at 570 nM[2].
Synonyms Phylloquinone, Phytomenadione, Phytonadione, Phyllohydroquinone
Molecular Weight 450.7
Formula C31H46O2
CAS No. 84-80-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (55.47 mM)

TargetMolReferences and Literature

1. Basset GJ, et al. Phylloquinone (Vitamin K1): Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22. 2. Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;22015:296721. 3. Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96(5):1113-8. 4. Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13. 5. Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46(4):409-12.

TargetMolCitations

1. Li Y, Xing Z, Wang S, et al.Disruption of biofilms in periodontal disease through the induction of phase transition by cationic dextrans.Acta Biomaterialia.2023

Related compound libraries

This product is contained In the following compound libraries:
Tobacco Monomer Library Bioactive Compounds Library Max Gut Microbial Metabolite Library FDA-Approved & Pharmacopeia Drug Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Clinical Compound Library Coagulation and Anticoagulation Compound Library Covalent Inhibitor Library Bioactive Compound Library Drug Repurposing Compound Library

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Keywords

Vitamin K1 84-80-0 Metabolism Others Endogenous Metabolite Vitamin K-1 Phylloquinone inhibit Vitamin K 1 Phytomenadione Phytonadione Inhibitor Phyllohydroquinone inhibitor

 

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