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Vitamin K1

Vitamin K1
Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.
Catalog No. T1075Cas No. 84-80-0
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Purity:99.82%
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Vitamin K1

Catalog No. T1075Cas No. 84-80-0
Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.
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Pack SizePriceAvailabilityQuantity
1 g$37In Stock
5 g$97In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Product Introduction

Bioactivity
Description
Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.
In vitro
Phylloquinone, also known as vitamin K1, is a vital compound produced solely by plants, green algae, and some cyanobacteria. It functions importantly in photosynthesis as an electron carrier in photosystem I and aids in forming protein disulfide bonds. Beyond its plant-based roles, phylloquinone is crucial for blood coagulation, bone, and vascular health in humans and other vertebrates, with green leafy vegetables and vegetable oil being its primary dietary sources[1]. Therapeutically, vitamin K1 exhibits a notable antiproliferative effect and induces apoptosis in specific cancer cell lines such as Caco-2, HT-29, and SW480, likely through the MAPK pathway, while also significantly reducing polyamine biosynthesis[2].
In vivo
Subjects who augmented their dietary vitamin K intake during the follow-up exhibited a 51% lower risk of developing diabetes compared to those who reduced or maintained their phylloquinone (vitamin K) consumption [3]. Furthermore, vitamin K supplementation countered bone deterioration in mice on a high-fat diet by modulating osteoblast and osteoclast activities, thereby preventing bone loss [4]. Additionally, topical application of vitamin K1 on skin has been effective in reducing pigmentation and resolving bruising, demonstrating significant improvement in wound healing, epithelialization time, hydroxyproline content, and tensile strength when compared to the control group [5].
Cell Research
Caco-2, HT-29, and SW480 cells are treated with increasing concentrations of vitamin K1 (10, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h. MTT is added to each dish and incubated for 2 h at 37°C. At the end of the incubation period, the medium is removed. The plate is read at 570 nM[2].
AliasPhylloquinone, Phytomenadione, Phytonadione, Phyllohydroquinone
Chemical Properties
Molecular Weight450.7
FormulaC31H46O2
Cas No.84-80-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (55.47 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2188 mL11.0939 mL22.1877 mL110.9385 mL
5 mM0.4438 mL2.2188 mL4.4375 mL22.1877 mL
10 mM0.2219 mL1.1094 mL2.2188 mL11.0939 mL
20 mM0.1109 mL0.5547 mL1.1094 mL5.5469 mL
50 mM0.0444 mL0.2219 mL0.4438 mL2.2188 mL

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