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Uridine triphosphate

Catalog No. T7711 CAS 63-39-8

Synonyms: UTP, Uridine 5'-triphosphate

Uridine triphosphate (Uridine 5'-triphosphate) increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor.

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Uridine triphosphate, CAS 63-39-8

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Description	Uridine triphosphate (Uridine 5'-triphosphate) increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor.
In vitro	Incubation of PANC-1 cells with UTP or MRS2768, a selective P2Y2 receptor agonist, resulted in a dose- and time-dependent increase of proliferation.?The messenger RNA transcript and protein of P2Y2 receptor were expressed in PANC-1 cells.?P2 receptor antagonist suramin and small interfering RNA against P2Y2 receptor significantly decreased the proliferative effect of UTP and MRS2768.?Activation of P2Y2 receptor by UTP transduced to phospholipase C, inositol 1,4,5-triphosphate (IP3), and protein kinase C. Uridine triphosphate-induced proliferation was mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increased phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K[1].
Cell Research	Proliferation was measured by immunoassay for bromodeoxyuridine incorporation into the pancreatic cell line PANC-1. Effect of UTP was assayed using selective P2 agonist and antagonist, small interfering RNA, intracellular signal inhibitors, and Western blot[1].

Synonyms	UTP, Uridine 5'-triphosphate
Molecular Weight	484.14
Formula	C9H15N2O15P3
CAS No.	63-39-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 150 mg/mL (309.83 mM)

References and Literature

1. Choi J H , Ji Y G , Lee D H . Uridine Triphosphate Increases Proliferation of Human Cancerous Pancreatic Duct Epithelial Cells by Activating P2Y2 Receptor[J]. Pancreas, 2013, 42(4):680-686. 2. Gündüz Dursun, Christian T , Daniel S , et al. Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation[J]. International Journal of Molecular Sciences, 2017, 18(2):269-.

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Keywords

Uridine triphosphate 63-39-8 Metabolism Others Endogenous Metabolite inhibit Uridine Triphosphate Inhibitor UTP Uridine 5'-triphosphate Uridine inhibitor

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