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Tucidinostat

Catalog No. T4481   CAS 1616493-44-7
Synonyms: HBI-8000, Chidamide, CS 055

Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.

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Tucidinostat Chemical Structure
Tucidinostat, CAS 1616493-44-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 58.00
10 mg In stock $ 92.00
25 mg In stock $ 171.00
50 mg In stock $ 277.00
100 mg In stock $ 443.00
200 mg In stock $ 621.00
500 mg In stock $ 925.00
1 mL * 10 mM (in DMSO) In stock $ 58.00
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Purity: 97.52%
Purity: 97.01%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.
Targets&IC50 HDAC1:95 nM (Cell-free), HDAC10:78 nM (Cell-free), HDAC3:67 nM (Cell-free), HDAC2:160 nM (Cell-free)
In vitro Tucidinostat shows potent antitumor activity and inhibits several human-derived tumour cell lines, such as HL-60, U2OS, LNCaP with GI50s of 0.4 ± 0.1, 2.0 ± 0.6, and 4.0 ± 1.2 μM, respectively. In addition, Tucidinostat shows less toxic to normal cells from human fetal kidney (CCC-HEK) and liver (CCCHEL)[1].
In vivo Tucidinostat (12.5-50 mg/kg, p.o.) dose-dependently reduces tumour size and tumour weight in mice bearing HCT-8 colorectal carcinoma, A549 lung carcinoma, BEL-7402 liver carcinoma, and MCF-7 breast carcinoma, and with no obvious body loss[1].
Synonyms HBI-8000, Chidamide, CS 055
Molecular Weight 390.41
Formula C22H19FN4O2
CAS No. 1616493-44-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 60 mg/mL (153.68 mM)

Ethanol: 1 mg/mL

TargetMolReferences and Literature

1. Ning ZQ, et al. Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9.

TargetMolCitations

1. Zha J, Zhong M, Pan G, et al.Stratification and therapeutic potential of ELL in cytogenetic normal acute myeloid leukemia.Gene.2022: 147110. 2. Shao J, Ye Z, Shen Z, et al.Chidamide improves gefitinib treatment outcomes in NSCLC by attenuating recruitment and immunosuppressive function of myeloid-derived suppressor cells.Biomedicine & Pharmacotherapy.2024, 173: 116306.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug-induced Liver Injury (DILI) Compound Library Anti-Breast Cancer Compound Library FDA-Approved & Pharmacopeia Drug Library Clinical Compound Library Histone Modification Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

Tucidinostat 1616493-44-7 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC HBI 8000 CS055 HBI-8000 Histone deacetylases Inhibitor inhibit Chidamide HBI8000 CS-055 CS 055 inhibitor

 

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