Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 58.00 | |
10 mg | In stock | $ 92.00 | |
25 mg | In stock | $ 171.00 | |
50 mg | In stock | $ 277.00 | |
100 mg | In stock | $ 443.00 | |
200 mg | In stock | $ 621.00 | |
500 mg | In stock | $ 925.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 58.00 |
Description | Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9. |
Targets&IC50 | HDAC1:95 nM (Cell-free), HDAC10:78 nM (Cell-free), HDAC3:67 nM (Cell-free), HDAC2:160 nM (Cell-free) |
In vitro | Tucidinostat shows potent antitumor activity and inhibits several human-derived tumour cell lines, such as HL-60, U2OS, LNCaP with GI50s of 0.4 ± 0.1, 2.0 ± 0.6, and 4.0 ± 1.2 μM, respectively. In addition, Tucidinostat shows less toxic to normal cells from human fetal kidney (CCC-HEK) and liver (CCCHEL)[1]. |
In vivo | Tucidinostat (12.5-50 mg/kg, p.o.) dose-dependently reduces tumour size and tumour weight in mice bearing HCT-8 colorectal carcinoma, A549 lung carcinoma, BEL-7402 liver carcinoma, and MCF-7 breast carcinoma, and with no obvious body loss[1]. |
Synonyms | HBI-8000, Chidamide, CS 055 |
Molecular Weight | 390.41 |
Formula | C22H19FN4O2 |
CAS No. | 1616493-44-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 60 mg/mL (153.68 mM)
Ethanol: 1 mg/mL
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tucidinostat 1616493-44-7 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC HBI 8000 CS055 HBI-8000 Histone deacetylases Inhibitor inhibit Chidamide HBI8000 CS-055 CS 055 inhibitor