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4-Phenylbutyric acid

Catalog No. T5886 CAS 1821-12-1

Synonyms: Benzenebutyric acid

4-Phenylbutyric acid (Benzenebutyric acid) is an inhibitor of HDAC,and is an antineoplastic agent.

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4-Phenylbutyric acid, CAS 1821-12-1

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.76%

Purity: 98.40%

Biological Description

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Storage & Solubility Information

Description	4-Phenylbutyric acid (Benzenebutyric acid) is an inhibitor of HDAC,and is an antineoplastic agent.
In vitro	Benzenebutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. Benzenebutyric acid in combination with ciglitizone results in enhanced growth arrest of cancer cells[1].

Synonyms	Benzenebutyric acid
Molecular Weight	164.2
Formula	C10H12O2
CAS No.	1821-12-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (761.27 mM)

References and Literature

1. Tsg-Hui C , Eva S . Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung[J]. Clinical Cancer Research, 2002, 8(4):1206-1212. 2. Gonçalo Frouco, Freitas F B , Martins C , et al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14[J]. Virus Research, 2017, 242:24-29.

Citations

1. Wang H, Chen J, Bai G, et al. mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4 + T Cell Apoptosis Mediated by ROS in Septic Immunosuppression. Mediators of Inflammation. 2022 2. Dong L, Xu M, Li Y, et al.SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway.Cell Death & Disease.2023, 14(6): 361. 3. Yu Y, Wu T, Zhang X, et al.Regorafenib activates oxidative stress by inhibiting SELENOS and potentiates oxaliplatin-induced cell death in colon cancer cells.European Journal of Pharmacology.2023: 175986.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library DNA Damage & Repair Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Anti-Breast Cancer Compound Library

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Keywords

4-Phenylbutyric acid 1821-12-1 Chromatin/Epigenetic DNA Damage/DNA Repair Microbiology/Virology Virus Protease HDAC 4-PBA 4Phenylbutyric acid inhibit Histone deacetylases Inhibitor 4 Phenylbutyric acid Benzenebutyric acid inhibitor

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