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Tianeptine sodium salt

Catalog No. T2402 CAS 30123-17-2

Synonyms: Tianeptine sodium

Tianeptine sodium salt is a selective serotonin reuptake enhancer (SSRE), used to treat major depressive episodes.

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Tianeptine sodium salt Chemical Structure

Tianeptine sodium salt, CAS 30123-17-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 52.00
50 mg	In stock	$ 62.00
100 mg	In stock	$ 92.00
200 mg	In stock	$ 135.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tianeptine sodium salt is a selective serotonin reuptake enhancer (SSRE), used to treat major depressive episodes.

In vitro

Tianeptine attenuates behavioral symptoms induced by peripheral, but not central, administration of LPS or IL-1β in rats. It normalizes the scaling ratio of NMDA receptor-mediated to AMPA/kainate receptor-mediated current amplitudes and prevents the stress-induced reduction in NMDA-EPSC inactivation. Tianeptine treatment prevents the increase in corticotropin-releasing factor (CRF) mRNA levels in the dBNST triggered by CMS and reduces CRF mRNA levels in the dBNST of non-stressed rats. In anesthetized rats, Tianeptine blocks stress-induced PB inhibition in the basolateral amygdala's CA1 region without affecting stress-induced LTP enhancement. Tianeptine administration under non-stress conditions enhances PB in the amygdala, hippocampus, and LTP in anesthetized rats. Tianeptine significantly decreases cell apoptosis in the rat temporal cortex and hippocampal dentate gyrus in both control and stressed animals but does not affect the Ammons horn. It notably increases extracellular concentrations of homovanillic acid and vanilmandelic acid in the nucleus accumbens and striatum. Intraperitoneal injection of 2.5 mg/kg Tianeptine in the nucleus accumbens alone increases extracellular dopamine.

Synonyms	Tianeptine sodium
Molecular Weight	458.93
Formula	C21H24ClN2NaO4S
CAS No.	30123-17-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 45.9 mg/mL (100 mM)

DMSO: 4.6 mg/mL (10 mM)

References and Literature

1. Kim SJ, et al. Neuropharmacology, 2006, 50(7), 824-833. 2. Vouimba RM, et al. Stress, 2006, 9(1), 29-40. 3. Castanon N, et al. Psychopharmacology (Berl), 2001, 154(1), 50-60. 4. Kole MH, et al. Eur J Neurosci, 2002, 16(5), 807-816. 5. Lucassen PJ, et al. Biol Psychiatry, 2004, 55(8), 789-796.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Parkinson's Disease Compound Library Serotonin Receptor-Targeted Compound Library Anti-Obesity Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Tianeptine sodium salt 30123-17-2 GPCR/G Protein Neuroscience 5-HT Receptor inhibit 5-hydroxytryptamine Receptor Serotonin Receptor Tianeptine sodium Tianeptine Inhibitor inhibitor

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