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Telotristat ethyl

Catalog No. T11897 CAS 1033805-22-9

Synonyms: LX1606

Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

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Telotristat ethyl, CAS 1033805-22-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 59.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 179.00
25 mg	In stock	$ 298.00
50 mg	In stock	$ 443.00
100 mg	In stock	$ 653.00
500 mg	In stock	$ 1,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 123.00

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Purity: 99.72%

Purity: 98.11%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

In vivo

Telotristat ethyl, at a dosage of 200 mg/kg administered orally once daily, has been shown to protect against inflammatory bowel disease (IBD) in mice, as evidenced by histopathology evaluations[1] and by alleviating the severity of colitis induced by trinitrobenzene sulfonic acid (TNBS)[2]. At various dosages (15, 50, 150, 300 mg/kg), Telotristat ethyl effectively reduces serotonin (5-HT) levels in the jejunum, though it does not affect serotonin levels in the brain or impact the enteric neuronal serotonin nor constitutive gastrointestinal motility at a 200 mg/kg dosage. Additionally, it prevents the TNBS-induced increase in blood neutrophil counts, highlighting its significant protective role in a mouse model of IBD, without altering serotonin content within the brain, even at differing concentrations (15, 50, 150, 300 mg/kg, administered orally once daily).

Synonyms	LX1606
Molecular Weight	574.98
Formula	C27H26ClF3N6O3
CAS No.	1033805-22-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 98.5 mg/mL (171.31mM)

References and Literature

1. Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model. 2. Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library EMA Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Approved Drug Library Bioactive Compound Library Orally Active Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Telotristat ethyl 1033805-22-9 Metabolism Hydroxylase inhibit LX-1606 LX1606 LX 1032 Inhibitor LX-1032 Tryptophan Hydroxylase LX 1606 LX1032 inhibitor

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