Tasosartan

Catalog No. T7797 CAS 145733-36-4

Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).

Tasosartan, CAS 145733-36-4

Pack Size	Availability	Price/USD
2 mg	In stock	106.00
5 mg	In stock	151.00
10 mg	In stock	244.00
25 mg	In stock	440.00
50 mg	In stock	660.00
1 mL * 10 mM (in DMSO)	In stock	162.00

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Purity 98.93%

HNMR HPLC COA

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).
Targets&IC50	angiotensin II type 2 (AT2) receptor : ic50 1.2 nM
In vivo	In vivo, tasosartan (p.o. or i.v.) blocked by 80% AT1 receptors 1 to 2 h after drug administration and still had a 40% effect at 32 h.
Animal Research	Pressor response to angiotensin-II administration in four groups of rats (n=3-5 each, weighing 343±8 g). Each rat is subjected to four separate bolus injections of angiotensin-II following the introduction of either the vehicle or graded doses of Tasosartan (0.3, 1.0, or 3.0 mg/kg, iv) [2].

Molecular Weight	411.46
Formula	C23H21N7O
CAS No.	145733-36-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 125 mg/mL (303.80 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Maillard M P , Rossat J , Brunner H R , et al. Tasosartan, enoltasosartan, and angiotensin II receptor blockade: The confounding role of protein binding[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 295(2):649-654. 2. Ellingboe J W , Collini M D , Quagliato D , et al. Metabolites of the Angiotensin II Antagonist Tasosartan:? The Importance of a Second Acidic Group[J]. journal of medicinal chemistry, 1998, 41(22):4251-4260.

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