Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 119.00 | |
2 mg | In stock | $ 178.00 | |
5 mg | In stock | $ 273.00 | |
10 mg | In stock | $ 398.00 | |
25 mg | In stock | $ 665.00 | |
50 mg | In stock | $ 947.00 | |
100 mg | In stock | $ 1,280.00 | |
500 mg | In stock | $ 2,570.00 |
Description | TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes. |
In vivo | In type II diabetes model db/db mice, TT01001 improved hyperglycemia, hyperlipidemia, and glucose intolerance, and its efficacy was equivalent to that of pioglitazone, without the pioglitazone-associated weight gain. Mitochondrial complex II + III activity of the skeletal muscle was significantly increased in db/db mice. TT01001 significantly suppressed the elevated activity of the complex II + III[2]. |
Synonyms | TT-01001, TT 01001, Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate |
Molecular Weight | 376.3 |
Formula | C15H19Cl2N3O2S |
CAS No. | 1022367-69-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 18 mg/mL (47.8 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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TT01001 1022367-69-6 Metabolism Mitochondrial Metabolism TT-01001 TT 01001 Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate inhibitor inhibit