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TPT-260 Dihydrochloride

Catalog No. T1856 CAS 2076-91-7

Synonyms: TPT-260, TPT 260, NSC55712, TPT260, TPU-260 Dihydrochloride

TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form.

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TPT-260 Dihydrochloride Chemical Structure

TPT-260 Dihydrochloride, CAS 2076-91-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 58.00
5 mg	In stock	$ 91.00
10 mg	In stock	$ 153.00
25 mg	In stock	$ 293.00
50 mg	In stock	$ 468.00
100 mg	In stock	$ 686.00
1 mL * 10 mM (in DMSO)	In stock	$ 91.00

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Purity: 97.93%

Purity: 92.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form.

Kinase Assay

Lyophilized Cdc42 protein is reconstituted to 5 mg/mL in a buffer consisting of 50 mM Tris, 0.5 mM MgCl2, 50 mM NaCl, 3% (wt/vol) sucrose, and 0.6% dextran. The stock solution is then diluted to 1 μM in 5 mM phosphate buffer, pH 7.4. Into a quartz cuvettete containing Cdc42 solution, aliquots of ZCL278 are added and incubated for 5 min before each fluorescent measurement. The excitation wavelength is 275 nm, and the fluorescence of tryptophan at 350 nm is measured after each addition. The titration curve is fitted using the equimolar specific binding model in GraphPad, and the Kd is calculated[1].

Synonyms	TPT-260, TPT 260, NSC55712, TPT260, TPU-260 Dihydrochloride
Molecular Weight	333.32
Formula	C8H14Cl2N4S3
CAS No.	2076-91-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (27 mM)

References and Literature

1. Matthews, H., Deakin, J., Rajab, M., Idris-Usman, M., & Nirmalan, N. (2017). Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. PLOS ONE, 12(3), e0173303. doi: 10.1371/journal.pone.0173303 2. Hawks, Z., Shimony, J., Rutlin, J., Grange, D., Christ, S., & White, D. (2017). Pretreatment cognitive and neural differences between sapropterin dihydrochloride responders and non-responders with phenylketonuria. Molecular Genetics And Metabolism Reports, 12, 8-13. doi: 10.12016/j.ymgmr.2017.01.2013

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TPT-260 Dihydrochloride 2076-91-7 Others Inhibitor TPT-260 inhibit TPT 260 TPT260 Dihydrochloride NSC55712 TPT260 TPU 260 Dihydrochloride NSC-55712 TPU-260 Dihydrochloride TPU260 TPT 260 Dihydrochloride NSC 55712 TPU 260 TPU260 Dihydrochloride TPU-260 inhibitor

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