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TDCPP

Catalog No. T5879 CAS 13674-87-8

Synonyms: Fyrol FR 2, Tris(1,3-dichloroisopropyl)phosphate

TDCPP (Fyrol FR 2) is classified under the chlorinated trialkyl organophosphate flame retardant (OPFR) group of compounds primarily utilized as additives in commercial products.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TDCPP, CAS 13674-87-8

Pack Size	Availability	Price/USD
50 mg	In stock	$ 43.00
100 mg	In stock	$ 59.00
200 mg	In stock	$ 80.00
1 mL * 10 mM (in DMSO)	In stock	$ 65.00

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	TDCPP (Fyrol FR 2) is classified under the chlorinated trialkyl organophosphate flame retardant (OPFR) group of compounds primarily utilized as additives in commercial products.
In vitro	A dose-dependent decrease of cell viability after TDCPP exposure with LC50 at 202 μg/mL. A concentration-dependent apoptotic sign was observed in HCECs after exposing to ≥2 μg/mL TDCPP. Endoplasmic reticulum stress induction was evidenced by up-regulation of its biomarker genes (ATF-4, CHOP, BiP, and XBP1). Furthermore, alternation of Bcl-2/Bax expression, mitochondrial membrane potential loss, cellular ATP content decrease, and caspase-3 and -9 activity increase were observed after exposing to 2 or 20 μg/mL TDCPP. Implicated the involvement of endoplasmic reticulum stress in TDCPP-induced HCEC apoptosis, probably mediated by mitochondrial apoptotic pathway. TDCPP exposure induced toxicity to human cornea.
Cell Research	Human corneal epithelial cells (HCECs) were cultured in DMEM supplemented with 10% FBS, 10 ng/mL EGF, and 1% penicillin-streptomycin solution in an incubator with 5% CO2 at 37℃.?After reaching confluence, HCECs were replanted into 6/24/ 96-well plates or petri dishes with different initial densities and cultured for 24 h to reach ~70% confluence.?Then, TDCPP dissolved in n-hexane was solvent-exchanged to DMSO and serially diluted by DMEM to achieve concentrations from 0.034 to 340 μg/mL.?For cell exposure, the culture medium was aspirated and treated with TDCPP solutions (DMSO <0.1%) for 24 h with 0.1% DMSO solution as vehicle control[1].

Synonyms	Fyrol FR 2, Tris(1,3-dichloroisopropyl)phosphate
Molecular Weight	430.9
Formula	C9H15Cl6O4P
CAS No.	13674-87-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (139.24 mM)

References and Literature

1. Xiang P , Liu R Y , Li C , et al. Effects of organophosphorus flame retardant TDCPP on normal human corneal epithelial cells: Implications for human health[J]. Environmental Pollution, 2017, 230:22-30.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TDCPP 13674-87-8 Others Fyrol FR 2 Tris(1,3-dichloroisopropyl)phosphate inhibit Inhibitor inhibitor

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