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Sparsentan

Catalog No. T5355 CAS 254740-64-2

Synonyms: RE-021, DARA-a

Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)

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Sparsentan, CAS 254740-64-2

Pack Size	Availability	Price/USD
5 mg	In stock	126.00
10 mg	In stock	207.00
25 mg	In stock	369.00
50 mg	In stock	612.00
100 mg	In stock	1017.00
1 mL * 10 mM (in DMSO)	In stock	207.00

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Purity 98.81%

HNMR HPLC COA

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Biological Description

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Storage & Solubility Information

Description	Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
Targets&IC50	Human angiotensin II , Human endothelin A , Rat angiotensin II , angiotensin II receptor , Endothelin A receptor

Synonyms	RE-021 , DARA-a
Purity	98.81%
Molecular Weight	592.8
Formula	C32H40N4O5S
CAS No.	254740-64-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 240 mg/mL (404.89 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Murugesan N, et al. Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. J Med Chem. 2005 Jan 13;48(1):171-9. 2. Komers R , Diva U , Inrig J K , et al. Study Design of the Phase 3 Sparsentan vs Irbesartan (DUPLEX) Study in Patients With Focal Segmental Glomerulosclerosis (FSGS)[J]. Kidney International Reports, 2020, 5(4). 3. Komers R , Gipson D S , Nelson P , et al. Efficacy and Safety of Sparsentan Compared With Irbesartan in Patients With Primary Focal Segmental Glomerulosclerosis: Randomized, Controlled Trial Design (DUET)[J]. Kidney International Reports, 2017:654-664.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Clinical Compound Library Endocrinology-Hormone Compound Library GPCR Compound Library Anti-Cardiovascular Disease Compound Library Drug Repurposing Compound Library

Related Products

Related compounds with same targets

Avosentan Atrasentan hydrochloride Atrasentan AVE 0991 TRV-120027 acetate (1234510-46-3 free base) TRV-120027 TFA Saralasin acetate(34273-10-4 free base) Acein acetate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.