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Soraprazan

Catalog No. T12977 CAS 261944-46-1

Synonyms: BYK61359

Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.

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Soraprazan, CAS 261944-46-1

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 447.00
25 mg	8-10 weeks	$ 1,530.00
50 mg	8-10 weeks	$ 1,990.00
100 mg	8-10 weeks	$ 3,280.00
1 mL * 10 mM (in DMSO)	8-10 weeks	$ 430.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.

In vitro

Soraprazan is a potent gastric H,K-ATPase inhibitor(IC50 :0.1 μM) when measured in ion-leaky vesicles in the presence of 1 mM potassium. Soraprazan also effectively inhibits dibutyryl cAMP-stimulated [14C]AP accumulation in isolated gastric glands(IC50 of 0.19 μM )(0.09-0.40 μM geometric mean from n=6 with 95% confidence limits). In ion-leaky vesicles, soraprazan is a potent k-competitive the H,K-ATPase inhibitor(Ki of 6.4 nM). Soraprazan binds to the H,K-ATPase in ion-leaky vesicles with a Kd of 26.4 nM and a Bmax of 2.89 nmol/mg.

Synonyms	BYK61359
Molecular Weight	367.44
Formula	C21H25N3O3
CAS No.	261944-46-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (408.23 mM)

References and Literature

1. Simon WA, et al. Soraprazan: setting new standards in inhibition of gastric acid secretion. J Pharmacol Exp Ther. 2007 Jun;321(3):866-74. Epub 2007 Mar 16.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Soraprazan 261944-46-1 Others BYK61359 BYK-61359 BYK 61359 inhibitor inhibit

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