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Sodium stibogluconate

Catalog No. T13013   CAS 16037-91-5
Synonyms: Stibogluconate trisodium nonahydrate

Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.

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Sodium stibogluconate Chemical Structure
Sodium stibogluconate, CAS 16037-91-5
Pack Size Availability Price/USD Quantity
500 mg In stock $ 178.00
1 g In stock $ 258.00
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Purity: 99.95%
Purity: 99.57%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.
In vitro 99% of SHP-1 activity at 10 μg/mL inhibited by Sodium stibogluconate. Similar degrees of inhibition of SHP-2 and PTP1B required 100 μg/mL Sodium stibogluconate. The inhibition of cellular PTPases by the Sodium stibogluconate is suggested by its rapid induction of tyrosine phosphorylation of cellular proteins in Baf3 cells and its augmentation of IL-3-induced Janus family kinase 2/Stat5 tyrosine phosphorylation and proliferation of Baf3 cells. The augmentation of the opposite effects of GM-CSF and IFN-α on TF-1 cell growth by Sodium stibogluconate indicate its broad activities in the signaling of various cytokines[1].
In vivo Sodium stibogluconate induces 61% growth inhibition of Renca tumors in BALB/c mice coincident with an increase (2-fold) in tumor-infiltrating macrophages. A combination of Sodium stibogluconate and IL-2 is more effective in inhibiting tumor growth (91%) and inducing tumor-infiltrating (4-fold)[2].
Synonyms Stibogluconate trisodium nonahydrate
Molecular Weight 910.9
Formula C12H38Na3O26Sb2
CAS No. 16037-91-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 6.67 mg/mL (7.32 mM), ultrasonic and adjust pH to 3 with 1M HCl

DMSO: < 1 mg/mL (insoluble or slightly soluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Pathak MK, et al. Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol. 2001 Sep 15;167(6):3391-7. 2. Fan K et al. Sodium Stibogluconate Interacts with IL-2 in Anti-Renca Tumor Action via a T Cell-Dependent Mechanism in Connection with Induction of Tumor-Infiltrating Macrophages. J Immunol. 2005 Nov 15;175(10):7003-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Metabolism Disease Compound Library Metabolism Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Phosphatase Inhibitor Library

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Keywords

Sodium stibogluconate 16037-91-5 Metabolism Phosphatase Stibogluconate trisodium nonahydrate inhibit Inhibitor inhibitor

 

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