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SecinH3

Catalog No. T6664   CAS 853625-60-2

SecinH3 is selective cytohesin inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
SecinH3 Chemical Structure
SecinH3, CAS 853625-60-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 33.00
5 mg In stock $ 72.00
10 mg In stock $ 126.00
25 mg In stock $ 238.00
50 mg In stock $ 425.00
100 mg In stock $ 628.00
1 mL * 10 mM (in DMSO) In stock $ 76.00
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Purity: 98.14%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SecinH3 is selective cytohesin inhibitor.
Targets&IC50 hCyh3:5.6 μM, hCyh1:5.4 μM, mCyh3:5.4 μM, hCyh2:2.4 μM, drosophila steppke:5.6 μM
In vitro In HepG2 cells, SecinH3 inhibits insulin signaling and associated gene expression. [1] SecinH3 also markedly inhibits migration of preadipocyte 3T3-L1 cells. [2] In the A549 cells, SecinH3 results in reduced proliferation by indirectly attenuating EGFR activation, and causes a synergistic antiproliferative effect when used in combination with gefitinib. [3]
In vivo In mice, SecinH3 increases the expression of gluconeogenic genes, reduces the expression of glycolytic, fatty acid and ketone body metabolism genes in the liver, reduces liver glycogen stores, and increases plasma insulin. [1] In mice bearing H460 xenografts, SecinH3 significantly retards tumor growth through its antiproliferative and pro-apoptotic effect. [3]
Kinase Assay Aptamer displacement screen: A library of small molecules screened in duplicate from Comgenex (10000 molecules) in 386 well plates by fluorescence polarization at an excitation wavelength of 485 nm using read-out at 520 nm in a reaction volume of 50 μL at 37° C. The screening buffer is PBS, pH 7.5, 3 mM MgCl2, 100 nM fluorecein-labelled M69 aptamer, 1 μM cytohesin-1 Sec7 at 100 μM compound concentrations.
Cell Research 3×103 cells per 96 well are seeded into a clear, flat bottom 96 well plate (TPP). After 24 h the cells are treated with the indicated concentrations of the inhibitors or solvent (final DMSO concentration 0.4%) in RPMI containing 50 ng/mL EGF or IGF-1, respectively. Medium is changed daily for 3 days and cell proliferation is analyzed with a MTT assas as described in the manufacturer's protocol using a Varioscan microplate reader. All assays are performed at least in triplicates. (Only for Reference)
Molecular Weight 460.51
Formula C24H20N4O4S
CAS No. 853625-60-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 4.6 mg/mL (10 mM)), with gentle warming

DMSO: 46.1 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Hafner M, et al. Nature. 2006, 444(7121), 941-944. 2. Torii T, et al. J Biol Chem. 2010, 285(31), 24270-24281. 3. Bill A, et al. PLoS One. 2012, 7(7), e41179.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Anti-Aging Compound Library NO PAINS Compound Library Oxidation-Reduction Compound Library Apoptosis Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

SecinH3 853625-60-2 Apoptosis SecinH 3 inhibit SecinH-3 Inhibitor inhibitor

 

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