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SPR741 acetate

Catalog No. T12992 CAS T12992

Synonyms: SPR741 acetate, NAB741 acetate, SPR741 acetate (1179330-52-9 free base)

SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.

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SPR741 acetate, CAS T12992

Pack Size	Availability	Price/USD
1 mg	In stock	$ 183.00
5 mg	In stock	$ 465.00
10 mg	In stock	$ 633.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,360.00
100 mg	In stock	$ 1,830.00

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Purity: 98.57%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.
In vitro	SPR741 acetate potentiates antibiotics ,SPR741 acetate are substrates of the AcrAB-TolC efflux pump in E. coli, effectively circumventing the contribution of this pump to intrinsic antibiotic resistance. The intrinsic resistance of E. coli to certain antibiotics that is mediated by both the outer membrane and the AcrAB-TolC efflux system can be overcome, or circumvented, by combining the antibiotic with SPR741 acetate but that potentiation of intrinsic resistance due primarily to efflux may be limited.[1]
In vivo	SPR741 acetate has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus makeing them sensitive to hydrophobic antibiotics. SPR741 acetate has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. Polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741 acetate in multiday rodent and nonhuman primate studies.[1]

Synonyms	SPR741 acetate, NAB741 acetate, SPR741 acetate (1179330-52-9 free base)
Molecular Weight	1052.18
Formula	C46H77N13O15
CAS No.	T12992

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 117.0 mg/mL (111.2 mM), Sonication is recommended.

References and Literature

1. Corbett D, et al. Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR74Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00200-17. 2. Eckburg PB, et al. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects. Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00892-19.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

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Keywords

SPR741 acetate T12992 Microbiology/Virology Antibacterial 1179330-52-9 NAB-741 Acetate NAB741 Acetate NAB 741 Acetate NAB741 acetate SPR741 acetate (1179330-52-9 free base) SPR 741 Acetate SPR-741 Acetate SPR741 Acetate 1179330-52-9 free base inhibitor inhibit

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