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Vaborbactam
🥰Excellent
Catalog No. T17210Cas No. 1360457-46-0
Alias RPX7009
Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.
Vaborbactam
🥰Excellent
Purity: 97.29%
Catalog No. T17210Alias RPX7009Cas No. 1360457-46-0
Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $149 | - | In Stock | |
| 5 mg | $342 | - | In Stock |
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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Batch Information
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Purity:97.29%
ee:100%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections. |
| In vitro | The β-lactamase inhibitor vaborbactam can also form an acyl-enzyme complex with Pseudomonas aeruginosa PBP3. We found that vaborbactam inhibits PBP3 (IC50 of 262 μM), and its binding to PBP3 increases the protein thermal stability by about 2°C[1]. |
| In vivo | In a neutropenic mouse thigh infection model, the administration of 100 mg/kg meropenem alone and in combination with various doses of vaborbactam against Klebsiella pneumoniae was evaluated. The results showed that intraperitoneal injection of 300 mg/kg meropenem combined with 50 mg/kg vaborbactam resulted in the greatest reduction in bacterial counts compared to the untreated control group[2]. |
| Synonyms | RPX7009 |
| Molecular Weight | 297.14 |
| Formula | C12H16BNO5S |
| Cas No. | 1360457-46-0 |
| Smiles | OB1O[C@H](CC(O)=O)CC[C@@H]1NC(=O)Cc1cccs1 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | H2O: 2 mg/mL (6.73 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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