Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SJG-136 is a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,500.00 | |
50 mg | 10-14 weeks | $ 1,950.00 | |
100 mg | 10-14 weeks | $ 2,950.00 |
Description | SJG-136 is a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA). |
Targets&IC50 | pBR322 DNA:(XL50)45 nM |
In vitro | SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50: 22.5 pM), A2780cisR (IC50: 24 pM), CH1 (IC50: 0.12 nM), CH1cisR (IC50: 0.6 nM), and SKOV-3 (IC50: 9.1 nM). SJG-136 also reduces the viability of a panel of canine cancer cells (GI50: ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure) [1][2]. |
In vivo | SJG-136-induced H2AX phosphorylation correlates well, albeit with lower sensitivity, compared to foci measurement. At a dosage of 0.30 mg/kg, SJG-136 exhibits a stronger antitumor effect on CMeC-1 tumors in mice than at 0.15 mg/kg, regardless of whether it is given as a single dose or once weekly for three weeks through intravenous administration [2]. |
Synonyms | NSC-694501 |
Molecular Weight | 556.61 |
Formula | C31H32N4O6 |
CAS No. | 232931-57-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (179.66 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SJG-136 232931-57-6 Others NSC 694501 NSC-694501 SJG 136 NSC694501 SJG136 inhibitor inhibit