Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.
Description | SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models. |
Targets&IC50 | p-ERK:0.250 μM, SHP2:0.07 μM |
Synonyms | SHP099 free base, SHP 099, SHP-099 |
Molecular Weight | 352.26 |
Formula | C16H19Cl2N5 |
CAS No. | 1801747-42-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 5.5 mg/mL (15.61 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SHP099 1801747-42-1 代谢 凋亡 PERK Phosphatase SHP099 free base inhibit SHP-099 SHP 099 Inhibitor inhibitor