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Rp-cAMPS triethylammonium salt

Catalog No. T12764 CAS 151837-09-1

Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 μM and 9.75 μM, respectively.

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Rp-cAMPS triethylammonium salt Chemical Structure

Rp-cAMPS triethylammonium salt, CAS 151837-09-1

Pack Size	Availability	Price/USD
500 μg	35 days	$ 195.00
1 mg	35 days	$ 297.00
5 mg	35 days	$ 1,160.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 μM and 9.75 μM, respectively.
Targets&IC50	PKA II:9.75 µM (ki), PKA I:ki： 6.05 µM
In vitro	A membrane-permeable competitive antagonist of cAMP that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme inhibits synaptic plasticity[1].
In vivo	The monosynaptic excitatory postsynaptic currents (EPSCs) induced at the PB-CeLC and BLA-CeLC synapses in tissue slices from arthritic rats were significantly reduced following treatment with Rp-cAMPS (10 μM, 15 min), whereas no reduction was observed in control neurons from healthy animals. This decline in EPSCs due to Rp-cAMPS is notably substantial when compared to the predrug artificial cerebrospinal fluid (ACSF) baseline levels measured in the identical neurons[1].

Molecular Weight	446.46
Formula	C16H27N6O5PS
CAS No.	151837-09-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251(3):757-62. 2. Fu Y, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008 Jul 16;4:26. 3. Kuriyama S, et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest Ophthalmol Vis Sci. 1995 Mar;36(3):730-6.

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