store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor.Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and promotes the phosphorylation of S473pAKT.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 328.00 | |
25 mg | In stock | $ 662.00 | |
50 mg | In stock | $ 995.00 | |
100 mg | In stock | $ 1,680.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor.Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and promotes the phosphorylation of S473pAKT. |
In vivo | In male C57BL/6 mice aged 6-7 weeks (fasted for 16 hours), administration of the Rheb inhibitor NR1 (30 mg/kg; intraperitoneal injection; single dose) resulted in significantly reduced mTORC1 activity in both kidney and skeletal muscle. Additionally, a clear band shift for T37/464E-BP1 was observed in skeletal muscle[1]. |
Molecular Weight | 578.3 |
Formula | C25H19BrCl2N2O3S |
CAS No. | 2216763-38-9 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (34.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rheb inhibitor NR1 2216763-38-9 PI3K/Akt/mTOR signaling mTOR Rheb inhibitor NR-1 inhibitor inhibit