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Reverse transcriptase-IN-1

Reverse transcriptase-IN-1
Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM.
Catalog No. T12715Cas No. 2380001-43-2
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Purity:99.14%
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Reverse transcriptase-IN-1

Catalog No. T12715Cas No. 2380001-43-2
Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
5 mg$222In Stock
10 mg$322In Stock
25 mg$547In Stock
50 mg$788In Stock
100 mg$1,080In Stock
500 mg$2,180In Stock
1 mL x 10 mM (in DMSO)$243In Stock
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Product Introduction

Bioactivity
Description
Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM.
Targets&IC50
HIV-1 RT:13.7 nM
In vitro
Reverse transcriptase-IN-1 has antiviral activity with EC50 values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 IIIB, E138K and K103N mutants, respectively[1].
In vivo
The PK study and safety assessment of Reverse transcriptase-IN-1 shows that it is absorbed with mean residence times (MRTs) of 11.8 hours (5 mg/kg, p.o.) and 11.4 hours (1 mg/kg, i.v.) at these two doses. The Cmax of Reverse transcriptase-IN-1 is 39.9 ng/mL at a dose of 5 mg/kg. The oral bioavailability of Reverse transcriptase-IN-1 is significantly improved to 16.5% at a dose of 5 mg/kg in rats. The intrinsic rat microsome clearance of Reverse transcriptase-IN-1 is 33.2 μL/min/mg proteins[1].
Chemical Properties
Molecular Weight447.45
FormulaC25H17N7O2
Cas No.2380001-43-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12 mg/mL (26.82 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2349 mL11.1744 mL22.3489 mL111.7443 mL
5 mM0.4470 mL2.2349 mL4.4698 mL22.3489 mL
10 mM0.2235 mL1.1174 mL2.2349 mL11.1744 mL
20 mM0.1117 mL0.5587 mL1.1174 mL5.5872 mL

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