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Rentiapril racemate

Catalog No. T16731 CAS 72679-47-1

Synonyms: (Rac)-SA-446, SA-446 racemate, (Rac)-Rentiapril

Rentiapril racemate (SA-446 racemate) is the racemate of Rentiapril.Rentiapril racemate has anti-inflammatory activity and may be used in glaucoma research.

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Rentiapril racemate, CAS 72679-47-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 117.00
5 mg	In stock	$ 283.00
10 mg	In stock	$ 419.00
25 mg	In stock	$ 686.00
50 mg	In stock	$ 996.00
100 mg	6-8 weeks	$ 1,570.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Rentiapril racemate (SA-446 racemate) is the racemate of Rentiapril.Rentiapril racemate has anti-inflammatory activity and may be used in glaucoma research.

In vivo

A three-month toxicity study of Rentiapril (CAS 80830-42-8), an angiotensin-converting enzyme (ACE) inhibitor, is conducted in Sprague-Dawley rats through oral administration. Dose levels of 0, 30, 125, 500, and 1000 mg/kg are tested in both sexes, with each experimental group consisting of 10 rats. Captopril, another ACE inhibitor, is used as a reference compound.At the highest dose of 1000 mg/kg, Rentiapril causes low food consumption and death in some animals, presenting signs of bloody feces and anemia. In males and females receiving 500 and 1000 mg/kg, there are low body weight gain, increases in water intake, urine volume, and serum BUN level, and decreases in various erythrocytic parameters. Kidney weight increases dose-dependently in both sexes. Histopathologically, renal changes in the 500 and 1000 mg/kg groups consist of proximal tubular degeneration, juxtaglomerular cell hyperplasia, and interstitial cell infiltration. Similar but milder changes in proximal tubules are present in the female 125 mg/kg group. Dead animals from the highest dose groups further show gastrointestinal hemorrhagic erosion and/or ulcer, decreased bone marrow erythropoiesis, and hepatocytic vacuolar degeneration. No pathological alterations are observed in rats from other Rentiapril-treated groups or in controls. These results indicate that the no-effect dose of Rentiapril in rats, following three months of oral administration, is 30 mg/kg in females and 125 mg/kg in males[1].

Synonyms	(Rac)-SA-446, SA-446 racemate, (Rac)-Rentiapril
Molecular Weight	313.39
Formula	C13H15NO4S2
CAS No.	72679-47-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (159.55 mM), Sonication is recommended.

References and Literature

1. Takase K, et al. Toxicity study of the angiotensin converting enzyme inhibitor rentiapril in rats. Arzneimittelforschung. 1995 Jan;45(1):15-8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rentiapril racemate 72679-47-1 Metabolism Angiotensin-converting Enzyme (ACE) (Rac)-SA-446 SA-446 racemate (Rac)-Rentiapril inhibitor inhibit

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