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Pyridoxal phosphate

Catalog No. T3578 CAS 54-47-7

Synonyms: PAL-P, Pyridoxyl phosphate, pyridoxal 5'-phosphate, PLP, Vitamin B6 phosphate, Pyridoxal 5′-phosphate

Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

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Pyridoxal phosphate, CAS 54-47-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Pyridoxal phosphate results in an immediate reduction in the rate of DNA synthesis. Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost.

Synonyms	PAL-P, Pyridoxyl phosphate, pyridoxal 5'-phosphate, PLP, Vitamin B6 phosphate, Pyridoxal 5′-phosphate
Molecular Weight	247.14
Formula	C8H10NO6P
CAS No.	54-47-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 40.5 mM

H2O: 20.23mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. 2. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.

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Keywords

Pyridoxal phosphate 54-47-7 Metabolism Microbiology/Virology Reverse Transcriptase Endogenous Metabolite PAL-P Pyridoxal Pyridoxyl phosphate pyridoxal 5'-phosphate Pyridoxyl inhibit Inhibitor PLP Vitamin B6 phosphate Pyridoxal 5′-phosphate inhibitor

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