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Pyridoxal phosphate

Name: Pyridoxal phosphate
Brand: TargetMol
SKU: T3578
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3578Cas No. 54-47-7

Alias Vitamin B6 phosphate, Pyridoxyl phosphate, pyridoxal 5'-phosphate, Pyridoxal 5′-phosphate, PLP, PAL-P

Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

Pyridoxal phosphate

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Purity: 99.18%

Catalog No. T3578Alias Vitamin B6 phosphate, Pyridoxyl phosphate, pyridoxal 5'-phosphate, Pyridoxal 5′-phosphate, PLP, PAL-PCas No. 54-47-7

Pack Size	Price	Availability
500 mg	$30	In Stock
1 g	$33	Backorder
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.18%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.
In vitro	Pyridoxal phosphate results in an immediate reduction in the rate of DNA synthesis. Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost.
Synonyms	Vitamin B6 phosphate, Pyridoxyl phosphate, pyridoxal 5'-phosphate, Pyridoxal 5′-phosphate, PLP, PAL-P

Chemical Properties

Molecular Weight	247.14
Formula	C₈H₁₀NO₆P
Cas No.	54-47-7
Smiles	C(OP(=O)(O)O)C=1C(C=O)=C(O)C(C)=NC1
Relative Density.	1.638 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (202.31 mM), Sonication is recommended.

H2O: 20.23 mM, Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0463 mL	20.2314 mL	40.4629 mL	202.3145 mL
5 mM	0.8093 mL	4.0463 mL	8.0926 mL	40.4629 mL
10 mM	0.4046 mL	2.0231 mL	4.0463 mL	20.2314 mL
20 mM	0.2023 mL	1.0116 mL	2.0231 mL	10.1157 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0809 mL	0.4046 mL	0.8093 mL	4.0463 mL
100 mM	0.0405 mL	0.2023 mL	0.4046 mL	2.0231 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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