Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.
Description | Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. |
In vitro | Pyridoxal phosphate results in an immediate reduction in the rate of DNA synthesis. Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost. |
Synonyms | PAL-P, Pyridoxyl phosphate, pyridoxal 5'-phosphate, PLP, Vitamin B6 phosphate, Pyridoxal 5′-phosphate |
Molecular Weight | 247.14 |
Formula | C8H10NO6P |
CAS No. | 54-47-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 40.5 mM
H2O: 20.23mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Pyridoxal phosphate 54-47-7 Metabolism Microbiology/Virology Reverse Transcriptase Endogenous Metabolite PAL-P Pyridoxal Pyridoxyl phosphate pyridoxal 5'-phosphate Pyridoxyl inhibit Inhibitor PLP Vitamin B6 phosphate Pyridoxal 5′-phosphate inhibitor