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Pyridoxal phosphate

Catalog No. T3578 CAS 54-47-7

Synonyms: PLP, PAL-P, pyridoxal 5'-phosphate, Pyridoxyl phosphate, Pyridoxal 5′-phosphate, Vitamin B6 phosphate

Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

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Pyridoxal phosphate, CAS 54-47-7

Pack Size	Availability	Price/USD
100 mg	In stock	$ 42.00
200 mg	In stock	$ 44.00
1 g	In stock	$ 58.00

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Purity: 99.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Pyridoxal phosphate results in an immediate reduction in the rate of DNA synthesis. Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost.

Synonyms	PLP, PAL-P, pyridoxal 5'-phosphate, Pyridoxyl phosphate, Pyridoxal 5′-phosphate, Vitamin B6 phosphate
Molecular Weight	247.14
Formula	C8H10NO6P
CAS No.	54-47-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (202.31 mM)

H2O: 20.23mM

References and Literature

1. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. 2. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Human Endogenous Metabolite Library Preclinical Compound Library Orally Active Compound Library NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Viral Compound Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Pyridoxal phosphate 54-47-7 Metabolism Microbiology/Virology Endogenous Metabolite Reverse Transcriptase PLP Pyridoxal Pyridoxyl PAL-P pyridoxal 5'-phosphate inhibit Pyridoxyl phosphate Vitamin B6 Phosphate Pyridoxyl Phosphate Inhibitor Pyridoxal Phosphate Pyridoxal 5′-phosphate Vitamin B6 phosphate inhibitor

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