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Endocrinology/Hormones Thyroid hormone receptor(THR) Propylthiouracil

Propylthiouracil

Catalog No. T1309   CAS 51-52-5
Synonyms: 6-Propyl-2-thiouracil, Pseudocapsaicin, 6-n-Propylthiouracil, NSC 6498, NSC 70461

Propylthiouracil is a thiourea derivative with an antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triiodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.

Propylthiouracil, CAS 51-52-5
Pack Size Availability Price/USD Quantity
2 mg In stock 20.00
10 mg In stock 32.00
25 mg In stock 42.00
50 mg In stock 52.00
100 mg In stock 65.00
200 mg In stock 81.00
500 mg In stock 100.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Propylthiouracil is a thiourea derivative with an antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triiodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.
Targets&IC50 Thyroid peripheral conversion,  
Synonyms 6-Propyl-2-thiouracil , Pseudocapsaicin , 6-n-Propylthiouracil , NSC 6498 , NSC 70461
Purity 99.94%
Molecular Weight 170.24
Formula C7H10N2OS
CAS No. 51-52-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 32 mg/mL (188 mM)

Ethanol: 16 mg/mL (94 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Sener G, et al. J Endocrinol,2006, 189(2), 257-269. 2. Zamoner A, et al. J Mol Endocrinol,2008, 40(3), 125-135. 3. Liu C, et al. Environ Sci Technol,2011, 45(2), 769-775. 4. Pantos C, et al. J Endocrinol,2003, 178(3), 427-435. 5. Gilbert ME, et al. Brain Res Dev Brain Res,2003, 145(1), 19-29.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Endocrinology-Hormones Library Hematopoietic Toxicity Compound Library FDA-approved Drug Library

Related Products

Related compounds with same targets
Taltirelin acetate KAT681 L-Thyroxine sodium salt pentahydrate CO23 Levothyroxine sodium MGL3196 Liothyronine sodium O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine

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