Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib -based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1].
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500 mg | 5 days | Inquiry |
Description | Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib -based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. |
In vitro | BTK-IAP PROTACs function as stoichiometric degraders, leading to the degradation of the BTK protein. This degradation occurs through the recruitment of the IAP E3 ligases family[1]. |
Molecular Weight | 260.28 |
Formula | C12H20O6 |
CAS No. | 1415800-32-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Propargyl-PEG4-acid 1415800-32-6 Others PropargylPEG4acid Propargyl-PEG-4-acid Propargyl PEG4 acid inhibitor inhibit