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Piperacillin sodium

Catalog No. T1213   CAS 59703-84-3
Synonyms: Sodium piperacillin, CL227193, Piperacillin sodium salt

(CL227193) )binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. Piperacillin Sodium is the sodium salt of piperacillin, a broad-spectrum semisynthetic, ampicillin-derived ureidopenicillin antibiotic with bactericidal activity. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.

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Piperacillin sodium Chemical Structure
Piperacillin sodium, CAS 59703-84-3
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25 mg In stock $ 30.00
50 mg Inquiry $ 42.00
100 mg Inquiry $ 57.00
200 mg Inquiry $ 87.00
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Purity: 99.11%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (CL227193) )binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. Piperacillin Sodium is the sodium salt of piperacillin, a broad-spectrum semisynthetic, ampicillin-derived ureidopenicillin antibiotic with bactericidal activity. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.
Kinase Assay Inhibition of Prostaglandin Formation: Recombinant COX-1 and COX-2 from rat (rCOX) and human (hCOX) expressed in a baculovirus system are purified and reconstituted with 2 mM phenol and 1 μM hematin. Then the cyclooxygenase activity is measured using a radiometric assay, and the specific activity of the final enzyme preparations used is between 20,000 and 35,000 units. Ketorolac (2 -15 μL) are diluted in DMSO and preincubated with the appropriate recombinant COX (3 -15 ng) at a final concentration of 0.01 to 1000 μM in a reaction mixture (150 μL) containing 50 mM Tris-HCl buffer (pH 7.9), 2 mM EDTA, 10% glycerol, 2 mM phenol, and 1 μM hematin for 10 minutes. The reaction is initiated by addition of [14C]arachidonic acid (50–60 mCi/mmol in a final concentration of 20 μM) and is terminated 45 seconds later by the addition of 100 μL of 0.2 N HCl and 750 μL of distilled water. The total reaction volume is then applied to a 1 mL C18 Sep-pak column that has previously been washed with 2 mL of methanol followed by 5 mL of deionized water. Oxygenated products are eluted with 3 mL of a mixture of acetonitrile/water/acetic acid (50:50:0.1, v/v/v) and quantified by liquid scintillation spectroscopy.
Synonyms Sodium piperacillin, CL227193, Piperacillin sodium salt
Molecular Weight 539.54
Formula C23H26N5NaO7S
CAS No. 59703-84-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 92 mg/mL (170.5 mM)

Ethanol: 93 mg/mL (172.4 mM)

DMSO: 93 mg/mL (172.4 mM)

TargetMolReferences and Literature

1. Williamson R, et al. Antimicrob Agents Chemother, 1980, 18(4), 629-637.

Related compound libraries

This product is contained In the following compound libraries:
Anti-COVID-19 Compound Library Pediatric Drug Library FDA-Approved Drug Library Drug-induced Liver Injury (DILI) Compound Library Drug Repurposing Compound Library Approved Drug Library NO PAINS Compound Library Beta-Lactam Compound Library Anti-Infection Compound Library

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Keywords

Piperacillin sodium 59703-84-3 Microbiology/Virology Antibacterial Antibiotic Bacterial CL 227193 Piperacillin CL-227193 Inhibitor inhibit Sodium piperacillin CL227193 Piperacillin sodium salt inhibitor

 

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