Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 40.00 | |
25 mg | In stock | $ 62.00 | |
50 mg | In stock | $ 92.00 | |
100 mg | In stock | $ 138.00 | |
500 mg | In stock | $ 338.00 |
Description | Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties. |
In vitro | Picrotoxinin (1 nM-1 mM) dose-dependently inhibits the action of the GABAA receptor and inhibits etomidate, propofol, diazepam, thiopentone sodium, loreclezole and allopregnanolone with IC50s of 0.55 μM, 0.49 μM, 0.35 μM, 0.50 μM, 0.14 μM and 0.44 μM in the presence of EC5 GABA, respectively[1]. |
Molecular Weight | 292.28 |
Formula | C15H16O6 |
CAS No. | 17617-45-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (307.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Picrotoxinin 17617-45-7 Membrane transporter/Ion channel Neuroscience Chloride channel GABA Receptor inhibitor inhibit