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Peficitinib

Name: Peficitinib
Brand: TargetMol
SKU: T6933
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6933Cas No. 944118-01-8

Alias JNJ-54781532, ASP015K

Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.

Peficitinib

🥰Excellent

Purity: 99.4%

Catalog No. T6933Alias JNJ-54781532, ASP015KCas No. 944118-01-8

Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.

Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$60	In Stock
10 mg	$106	In Stock
25 mg	$192	In Stock
50 mg	$297	In Stock
100 mg	$463	In Stock
200 mg	$678	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock

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Batch Information

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Purity:99.4%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
Targets&IC50	JAK2:5.0 nM, JAK1:3.9 nM, TYK2:4.8 nM, JAK3:0.7 nM
In vitro	ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). [1]
In vivo	In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score. [1]
Synonyms	JNJ-54781532, ASP015K

Chemical Properties

Molecular Weight	326.39
Formula	C₁₈H₂₂N₄O₂
Cas No.	944118-01-8
Smiles	[H][C@]12CC3C[C@]([H])(CC(O)(C3)C1)C2Nc1c(cnc2[nH]ccc12)C(N)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <1 mg/mL

Ethanol: <1 mg/mL

DMSO: 60 mg/mL (183.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0638 mL	15.3191 mL	30.6382 mL	153.1910 mL
5 mM	0.6128 mL	3.0638 mL	6.1276 mL	30.6382 mL
10 mM	0.3064 mL	1.5319 mL	3.0638 mL	15.3191 mL
20 mM	0.1532 mL	0.7660 mL	1.5319 mL	7.6595 mL
50 mM	0.0613 mL	0.3064 mL	0.6128 mL	3.0638 mL
100 mM	0.0306 mL	0.1532 mL	0.3064 mL	1.5319 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc