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Pachymic acid

Catalog No. T6S0619   CAS 29070-92-6
Synonyms: 3-O-Acetyltumulosic acid

Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.

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Pachymic acid Chemical Structure
Pachymic acid, CAS 29070-92-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 72.00
5 mg In stock $ 177.00
10 mg In stock $ 277.00
25 mg In stock $ 527.00
50 mg In stock $ 762.00
100 mg In stock $ 1,070.00
1 mL * 10 mM (in DMSO) In stock $ 197.00
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Purity: 100%
Purity: 99.91%
Purity: 99.43%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.
In vitro Pachymic acid(PA) exhibited anti-tumor effects in vitro accompanied by induction of G2/M phase arrest and apoptosis in NCI-H23 and NCI-H460 lung cancer cells.?Mechanistically, our data showed that PA induced reactive oxygen species (ROS) production, resulting in the activation of both c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in lung cancer cells.?Moreover, blockage of ROS production reversed PA-induced JNK and ER stress activation.?Finally, PA inhibited the growth of NCI-H23 xenograft tumors without causing any host toxicity, and inhibited cell proliferation and induction of apoptosis of tumor cells in tumor xenograft tissues[1].PA significantly reduced cell growth in a dose- and time-dependent fashion. Meanwhile, cell cycle arrest at G0 phase was induced by PA. PA also significantly inhibited cancer cell migration, invasion in a dose-dependent manner. Interestingly,demonstrated that cancer cell adhesion ability was suppressed dose-dependently, which may contribute to the inhibition of cell invasion. Finally, showed that PA inhibited AKT and ERK signaling pathways. And oncoproteins, such as PCNA, ICAM-1 and RhoA which are involved intumorigenesis, were also downregulated by PA[1].
Cell Research The anti-proliferative ability of PA on lung cancer cells was assessed by MTT, colony formation and EdU proliferation assays.?Flow cytometric analysis was used to detect cell cycle changes.?Apoptosis was determined by annexin V/PI double-staining and the DNA ladder formation assays.?The expressions of the apoptosis-related proteins were analysed by western blot[1].
Synonyms 3-O-Acetyltumulosic acid
Molecular Weight 528.76
Formula C33H52O5
CAS No. 29070-92-6


keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7 mg/mL (13.24 mM), sonification is recommended.

TargetMolReferences and Literature

1. Ma J, et al. Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells. Cancer Cell Int. 2015 Aug 5;15:78. 2. Chen Y, et al. Pachymic acid inhibits tumorigenesis in gallbladder carcinoma cells. Int J Clin Exp Med. 2015 Oct 15;8(10):17781-8.

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Terpene Natural Product Library Oxidation-Reduction Compound Library Antioxidant Compound Library Selected Plant-Sourced Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Prostate Cancer Compound Library Anti-Lung Cancer Compound Library Antidepressant Compound Library Chinese Pharmacopoeia Natural Product Library

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Pachymic acid 29070-92-6 Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Akt ERK PKB Protein kinase B inhibit Extracellular signal regulated kinases Inhibitor 3-O-Acetyltumulosic acid inhibitor