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PS47

Catalog No. T24677 CAS 1180676-33-8

Synonyms: PS 47, PS-47

PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.

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PS47, CAS 1180676-33-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 42.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 208.00
50 mg	In stock	$ 337.00
100 mg	In stock	$ 542.00
500 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 98.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.
In vitro	PS47 shows very low binding affinity or no binding to PDK1 (Kd>200 μM)[1].

Synonyms	PS 47, PS-47
Molecular Weight	286.75
Formula	C17H15ClO2
CAS No.	1180676-33-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL(313.86 mM), Sonication is recommended.

References and Literature

1. Hindie V , Stroba A , Zhang H , et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.[J]. Nature Chemical Biology, 2009, 5(10):758. 2. Pastor-Flores D , Schulze J O , A Bahí, et al. PIF-pocket as a target for C. albicans Pkh selective inhibitors.[J]. Acs Chemical Biology, 2013, 8(10):2283-2292. 3. Anthony TG, Polley SD, Vogler AP, Conway DJ. Evidence of non-neutral polymorphism in Plasmodium falciparum gamete surface protein genes Pfs47 and Pfs48/45. Mol Biochem Parasitol. 2007 Dec;156(2):117-23. Epub 2007 Jul 20. PubMed PMID: 17826852. 4. Jayaswal RK, Lee YI, Wilkinson BJ. Cloning and expression of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity. J Bacteriol. 1990 Oct;172(10):5783-8. PubMed PMID: 1976618; PubMed Central PMCID: PMC526895.

Related compound libraries

This product is contained In the following compound libraries：

Glycometabolism Compound Library Anti-Liver Cancer Compound Library Metabolism Compound Library Anti-Cancer Metabolism Compound Library Kinase Inhibitor Library Anti-Lung Cancer Compound Library NO PAINS Compound Library Antidepressant Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PS47 1180676-33-8 PI3K/Akt/mTOR signaling PDK control inhibit Inhibitor PS 47 PS48 PDK-1 PS-47 negative E-isomer inhibitor

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