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PD 407824

Catalog No. T16446 CAS 622864-54-4

Synonyms: PD-407824

PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).

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PD 407824, CAS 622864-54-4

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Purity: 98.02%

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Description	PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).
Targets&IC50	Chk1:47 nM, WEE1:97 nM
In vitro	Inhibiting Wee1 and Chk1 kinases can lead to the disappearance of DNA damage-induced G2 checkpoint. Research findings indicate that PD 407824 selectively acts on CHK1 and WEE1, with IC50 values exceeding 3.4µM and 3.75µM for PKC and Cdk4, respectively[3].

Synonyms	PD-407824
Molecular Weight	328.32
Formula	C20H12N2O3
CAS No.	622864-54-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (304.88 mM), Sonication is recommended.

References and Literature

1. Palmer BD, et al. 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase WeeStructure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem. 2006 Aug 10;49(16):4896-911. 2. Feng L, et al. Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell Rep. 2016 May 31;15(9):2063-75. 3. Smaill JB,et al. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem. 2008 Jun;43(6):1276-96.

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Keywords

PD 407824 622864-54-4 Cell Cycle/Checkpoint Chk Wee1 PD-407824 PD407824 inhibitor inhibit

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