Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 132.00 | |
5 mg | In stock | $ 323.00 | |
10 mg | In stock | $ 550.00 | |
25 mg | In stock | $ 887.00 | |
50 mg | In stock | $ 1,220.00 | |
100 mg | In stock | $ 1,630.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 339.00 |
Description | WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases. |
Targets&IC50 | Wee1:<10 nM |
In vitro | WEE1-IN-3 inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively. ?WEE1 is overexpressed in various cancer types,?WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?ΝΑ repair before mitotic entry.?Normal cells repair damaged DNA during GI arrest.?Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. |
Synonyms | JUN76288 |
Molecular Weight | 497.59 |
Formula | C28H31N7O2 |
CAS No. | 2272976-28-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (502.42 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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WEE1-IN-3 2272976-28-8 Cell Cycle/Checkpoint Wee1 WEE1IN3 JUN76288 cycle Inhibitor inhibit cell JUN 76288 JUN-76288 WEE-1-IN-3 WEE1 IN 3 Anticancer inhibitor