Home Tools
Log in
Cart

WEE1-IN-3

Catalog No. T8916   CAS 2272976-28-8
Synonyms: JUN76288

WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
WEE1-IN-3 Chemical Structure
WEE1-IN-3, CAS 2272976-28-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 132.00
5 mg In stock $ 323.00
10 mg In stock $ 550.00
25 mg In stock $ 887.00
50 mg In stock $ 1,220.00
100 mg In stock $ 1,630.00
1 mL * 10 mM (in DMSO) In stock $ 339.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 98.61%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
Targets&IC50 Wee1:<10 nM
In vitro WEE1-IN-3 inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively. ?WEE1 is overexpressed in various cancer types,?WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?ΝΑ repair before mitotic entry.?Normal cells repair damaged DNA during GI arrest.?Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair.
Synonyms JUN76288
Molecular Weight 497.59
Formula C28H31N7O2
CAS No. 2272976-28-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (502.42 mM), sonification is recommended.

TargetMolReferences and Literature

1. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Inhibitor Library Cell Cycle Compound Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets
ZNL 02-096 ZN-c3 RP-6306 Adavosertib Debio-0123 GSK-1520489A PD0166285 PD 407824

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

WEE1-IN-3 2272976-28-8 Cell Cycle/Checkpoint Wee1 WEE1IN3 JUN76288 cycle Inhibitor inhibit cell JUN 76288 JUN-76288 WEE-1-IN-3 WEE1 IN 3 Anticancer inhibitor

 

TargetMol