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Oridonin

Catalog No. T2790 CAS 28957-04-2

Synonyms: NSC-250682, Rubescenin, Isodonol, Rubescensin A

Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Oridonin, CAS 28957-04-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 45.00
50 mg	In stock	$ 89.00
100 mg	In stock	$ 144.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.5%

Purity: 99.04%

Purity: 94.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.
Targets&IC50	Akt2:8.9 μM, Akt1:8.4μM
In vivo	LD50: Mice 35-40 mg/kg. [4]
Source	Natural Products > Lamiaceae > Isodon

Synonyms	NSC-250682, Rubescenin, Isodonol, Rubescensin A
Molecular Weight	364.44
Formula	C20H28O6
CAS No.	28957-04-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 28 mg/mL (76.83 mM)

DMSO: 72 mg/mL (197.57 mM)

References and Literature

1. Ikezoe T, et al. Int J Oncol, 2003, 23(4), 1187-1193. 2. Ikezoe T, et al. Mol Cancer Ther, 2005, 4(4), 578-586. 3. Cui Q, et al. J Pharmacol Sci, 2007, 105(4), 317-325.

Citations

1. Li L, Song J, Zhang M, et al. Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy. Acta Pharmacologica Sinica. 2022: 1-15. 2. An Y, Zhu J, Wang X, et al. Oridonin Delays Aging Through the AKT Signaling Pathway. Frontiers in Pharmacology. 2022: 1823 3. Li L, Cheng S Q, Guo W, et al. Oridonin prevents oxidative stress‐induced endothelial injury via promoting Nrf‐2 pathway in ischaemic stroke. Journal of Cellular and Molecular Medicine. 2021 4. Yan H, Zhang R, Yan G, et al.Validation of baicalein and oridonin as nonspecific SARS‐CoV‐2 main protease inhibitors.Phytotherapy Research.2023

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Kinase Inhibitor Library Glycolysis Compound Library Anti-Pancreatic Cancer Compound Library Immunology/Inflammation Compound Library Anti-Cancer Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compounds Library Max Antibiotics Library

Related Products

Related compounds with same targets

K-80003 Buddlejasaponin IV Norathyriol Damnacanthal CCT128930 MK-2206 free base PI3K/Akt/mTOR-IN-2 Herbacetin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Oridonin 28957-04-2 Cytoskeletal Signaling Microbiology/Virology PI3K/Akt/mTOR signaling Akt Antibacterial NSC-250682 Bacterial Rubescenin Inhibitor Isodonol NSC 250682 NSC250682 inhibit Protein kinase B PKB Rubescensin A inhibitor

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