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Ophiopogonin D'

Catalog No. TN1071 CAS 65604-80-0

Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.

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Ophiopogonin D', CAS 65604-80-0

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Purity: 98%

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Description

Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.

In vitro

In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, Ophiopogonin D' (OD') noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 μM, respectively[1].

Molecular Weight	855.02
Formula	C44H70O16
CAS No.	65604-80-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.Evid Based Complement Alternat Med. 2014;2014:594354. 2. Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132. 3. Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9.

Related Products

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N-Caffeoyltryptophan (+)-Syringaresinol 5-Feruloylquinic acid Ophiopogonin D' Tenovin-6 Hydrochloride MC2184 SIRT7 inhibitor 97491 SRT 2183

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Keywords

Ophiopogonin D' 65604-80-0 DNA损伤和修复表观遗传代谢 Sirtuin UGT inhibit Inhibitor inhibitor

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