keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 123.00 | |
2 mg | In stock | $ 196.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 538.00 | |
25 mg | In stock | $ 855.00 | |
50 mg | In stock | $ 1,150.00 | |
100 mg | In stock | $ 1,550.00 | |
500 mg | In stock | $ 2,970.00 |
Description | Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2. |
In vitro | NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7 which may involve in the development of vascular hypertension. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1]. |
In vivo | NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats[1]. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124 which suggests that orexin neurons are downstream targets of NPW [2]. |
Synonyms | NPW-23 |
Molecular Weight | 2584.01 |
Formula | C119H183N35O28S |
CAS No. | 383415-79-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
You can also refer to dose conversion for different animals. More
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Neuropeptide W-23(human) 383415-79-0 Others Neuropeptide W23(human) Neuropeptide W-23 hypetension anorexigenic effect Neuropeptide W 23(human) Neuropeptide W-23 (human) NPW23 GPR7 Inhibitor Neuropeptide W GPR8 NPBW1 NPW-23 NPBW2 NPW 23 inhibit inhibitor