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Piclozotan

Catalog No. T28414 CAS 182415-09-4

Synonyms: SUN-N-4057, SUN4057, SUNN-4057, SUN-4057, SUNN4057

Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model, ameliorating motor complications in patients with advanced Parkinson's disease.

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Piclozotan, CAS 182415-09-4

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Purity: 99%

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Description

In vivo

Piclozotan (SUN N4057) (0.018 and 0.036 mg/kg/h; continuous subcutaneous infusion; 3 to 4 weeks; Parkinsonian rats) significantly lengthened the duration of rotational behavior by 26% and attenuated the increase in striatal levodopa-derived extracellular dopamine levels compared with the control group. Piclozotan (0.018 and 0.036 mg/kg/h, plasma concentrations 5.3±0.7 and 14.3±2.9 ng/ml) reduced levodopa-induced forelimb hyperkinesia by 55% and 69%, respectively, at 1h relative to the control.[1]

Synonyms	SUN-N-4057, SUN4057, SUNN-4057, SUN-4057, SUNN4057
Molecular Weight	409.91
Formula	C23H24ClN3O2
CAS No.	182415-09-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tani Y, et al Effects of piclozotan (SUN N4057), a partial serotonin 1A receptor agonist, on motor complications induced by repeated administration of levodopa in parkinsonian rats. Eur J Pharmacol. 2010;649(1-3):218-223. 2. Mondick JT, et al. Population pharmacokinetics of the selective serotonin 5-HT1A receptor partial agonist piclozotan. Am J Ther. 2009;16(2):106-115. 3. Kamei K, et al. Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan. Bioorg Med Chem. 2006;14(6):1978-1992. 4. Ferro JM, et al. Other neuroprotective therapies on trial in acute stroke. Cerebrovasc Dis. 2006;21 Suppl 2:127-130.

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Keywords

Piclozotan 182415-09-4 GPCR/G Protein Neuroscience 5-HT Receptor SUN-N-4057 SUN-N4057 SUN 4057 SUN4057 SUNN 4057 SUN-N 4057 SUNN-4057 SUN-4057 SUNN4057 inhibitor inhibit

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