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NU2058

Catalog No. T3186 CAS 161058-83-9

Synonyms: O6-(Cyclohexylmethyl)guanine, O(6)-Cyclohexylmethylguanine

NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NU2058, CAS 161058-83-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 45.00
10 mg	In stock	$ 81.00
25 mg	In stock	$ 136.00
50 mg	In stock	$ 211.00
100 mg	In stock	$ 328.00

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Purity: 99.95%

Purity: 98.43%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
Targets&IC50	CDK1:26 μM, CDK2:17 μM

Synonyms	O6-(Cyclohexylmethyl)guanine, O(6)-Cyclohexylmethylguanine
Molecular Weight	247.3
Formula	C12H17N5O
CAS No.	161058-83-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 24.7 mg/mL(100 mM)

References and Literature

1. Rigas AC, et al. Oncogene. 2007 Dec 6;26(55):7611-9. 2. Jensen LH, et al. Y Res. 2005 Aug 15;65(16):7470-7. 3. Knockaert M, et al. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. 4. Arris CE, et al. J Med Chem. 2000 Jul 27;43(15):2797-804.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Anti-Infection Compound Library NO PAINS Compound Library Anti-Pancreatic Cancer Compound Library DNA Damage & Repair Compound Library Cell Cycle Compound Library Anti-Viral Compound Library

Related Products

Related compounds with same targets

Topoisomerase IV inhibitor 1 Mitoxantrone dihydrochloride Topoisomerase inhibitor 2 Guajadial B Podofilox Heveaflavone 1,4-Naphthoquinone Topovale

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NU2058 161058-83-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Topoisomerase CDK NU 2058 guanine-based inhibit Cyclin dependent kinase anti-cancer competitive Inhibitor O6-(Cyclohexylmethyl)guanine ATP O(6)-Cyclohexylmethylguanine NU-2058 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.