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NS13001

Catalog No. T16345 CAS 1063331-94-1

Synonyms: N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine, N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine

NS13001 (N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine) is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NS13001, CAS 1063331-94-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
5 mg	In stock	$ 139.00
10 mg	In stock	$ 243.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 588.00
100 mg	In stock	$ 852.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.55%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

SK3:0.14 μM(EC50), SK2:(EC50)1.8 μM

Synonyms	N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine, N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine
Molecular Weight	353.81
Formula	C17H16ClN7
CAS No.	1063331-94-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (254.37 mM), Sonification is recommended.

References and Literature

1. Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.

Related compound libraries

This product is contained In the following compound libraries：

Ion Channel Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Potassium Channel Blocker Library NO PAINS Compound Library Orally Active Compound Library Anti-Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NS13001 1063331-94-1 Membrane transporter/Ion channel Potassium Channel Inhibitor NS 13001 KcsA inhibit N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine NS-13001 inhibitor

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