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N-Deshydroxyethyl Dasatinib

Catalog No. T18750 CAS 910297-51-7

Synonyms: N-Deshydroxyethyl BMS-354825

N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER.N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

N-Deshydroxyethyl Dasatinib Chemical Structure

N-Deshydroxyethyl Dasatinib, CAS 910297-51-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 543.00
50 mg	In stock	$ 789.00
100 mg	In stock	$ 1,080.00
500 mg	In stock	$ 2,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 226.00

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Purity: 95.96%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	N-Deshydroxyethyl BMS-354825
Molecular Weight	443.95
Formula	C20H22ClN7OS
CAS No.	910297-51-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49.5 mg/mL (111.5 mM), Sonication is recommended.

References and Literature

1. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. 2. Thappali SR, et al. Simultaneous determination of methotrexate, dasatinib and its active metabolite N- deshydroxyethyl dasatinib in rat plasma by LC-MS/MS: method validation and application to pharmacokinetic study. Arzneimittelforschung. 2012;62(12):624-630.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Immunology/Inflammation Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-Deshydroxyethyl Dasatinib 910297-51-7 Apoptosis Metabolism Others Drug Metabolite IAP N-Deshydroxyethyl BMS-354825 N-Deshydroxyethyl BMS354825 N-Deshydroxyethyl BMS 354825 inhibitor inhibit

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