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N-Bis(2-hydroxypropyl)nitrosamine

Catalog No. T19445 CAS 53609-64-6

Synonyms: Di(2-hydroxypropyl)nitrosamine, DHPN, Diisopropanolnitrosamine

N-Bis(2-hydroxypropyl)nitrosamine (DHPN) is a carcinogenic agent.

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N-Bis(2-hydroxypropyl)nitrosamine Chemical Structure

N-Bis(2-hydroxypropyl)nitrosamine, CAS 53609-64-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 80.00
50 mg	In stock	$ 97.00
100 mg	In stock	$ 155.00
200 mg	In stock	$ 263.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

N-Bis(2-hydroxypropyl)nitrosamine (DHPN) is a carcinogenic agent.

In vivo

The carcinogenic activity of orally administered N-bis(2-hydroxypropyl)-nitrosamine (DHPN) in male Wistar rats was evaluated with respect to its dose. DHPN was administered at two doses, 100 ppm and 500 ppm, in the drinking water to rats for 25 to 52 weeks. Tumors developed in the lung, liver, and thyroid of rats receiving 100 ppm DHPN and in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats receiving 500 ppm DHPN. The principal target organ was the lung in rats receiving either 100 or 500 ppm DHPN, indicating that the carcinogenic action of these doses of DHPN was similar to that of higher doses previously reported[2].

Synonyms	Di(2-hydroxypropyl)nitrosamine, DHPN, Diisopropanolnitrosamine
Molecular Weight	162.19
Formula	C6H14N2O3
CAS No.	53609-64-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (616.56 mM)

References and Literature

1. Zhang J, et al. Low dose of Bisphenol A enhance the susceptibility of thyroid carcinoma stimulated by DHPN and iodine excess in F344 rats. Oncotarget. 2017 Jul 22;8(41):69874-69887. 2. Konishi Y, et al. Effect of dose on the carcinogenic activity of orally administered N-bis(2-hydroxypropyl)nitrosamine in rats. Gan. 1978 Aug;69(4):573-7. 3. Son HY, et al. Specificity of co-promoting effects of caffeine on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine. Toxicol Pathol. 2004 May-Jun;32(3):338-44.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-Bis(2-hydroxypropyl)nitrosamine 53609-64-6 Others inhibit Di(2-hydroxypropyl)nitrosamine NBis(2hydroxypropyl)nitrosamine N Bis(2 hydroxypropyl)nitrosamine Inhibitor DHPN Diisopropanolnitrosamine inhibitor

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