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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat

Catalog No. T7657 CAS 149635-73-4

Synonyms: MOG (35-55)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a truncated peptide derived from the human Myelin Oligodendrocyte Glycoprotein (MOG).

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat Chemical Structure

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat, CAS 149635-73-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 56.00
2 mg	In stock	$ 86.00
5 mg	In stock	$ 156.00
10 mg	In stock	$ 249.00
25 mg	In stock	$ 425.00
50 mg	In stock	$ 617.00

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Purity: 93.16%

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Description	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a truncated peptide derived from the human Myelin Oligodendrocyte Glycoprotein (MOG).
In vitro	CD8CD3 and CD4CD3 cells were 86% and 94% pure of total CD3 cells after CD8/CD4 bead enrichment, respectively.?These cells were stimulated by MOG35-55 peptide and applied to proliferation assays.?Although the CD8 T cells had a generally lower response to MOG35-55 than CD4 T cells, the response of CD8 T cells was not always dependent on CD4.?CD8 T cell secreted less IFN-γ and IL-4 compared with CD4 T cells[1].
In vivo	EAE was induced in wildtype B6 na?ve mice by adoptive transfer of MOG35-55-specific T cells from B6 active-induced EAE (aEAE) mice.?A similar EAE score and slight inflammation and demyelination were found in naive B6 mice after transferring of CD8 T cells from immunized B6 mice compared with transfer of CD4 T cells[1].
Animal Research	Female C57BL/6 mice (n?=?20) were induced by myelin oligodendrocyte glycoprotein (MOG)35-55 peptide.?At 14 days after immunization, T cells were isolated from the spleen and purified as CD4 and CD8 T cells by using CD4 and CD8 isolation kits, and then the purity was determined by flow cytometric analysis.?These cells were stimulated by MOG35-55 peptide and applied to proliferation assays.?The interferon-gamma (IFN-γ) and interleukin (IL)-4 secretion of supernatant of cultured CD4 and CD8 T cells were measured by enzyme-linked immunosorbent assays (ELISA).?For adoptive transfer, recipient mice were injected with MOG35-55-specific CD8 or CD4 T cells.?EAE clinical course was measured by EAE score at 0-5 scale and spinal cord was examined by staining with hematoxylin and eosin and Luxol fast blue staining[1].

Synonyms	MOG (35-55)
Molecular Weight	2581.95
Formula	C118H177N35O29S
CAS No.	149635-73-4

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: Insoluble

References and Literature

1. Peng Y, Zhu FZ, Chen ZX,et al.Characterization of myelin oligodendrocyte glycoprotein (MOG)35-55-specific CD8+ T cells in experimental autoimmune encephalomyelitis[J].Chin Med J (Engl). 2019 Dec 20;132(24):2934-2940. 2. Ichikawa M , , Johns T G , Liu J , , et al. Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55[J]. Journal of Immunology, 1996, 157(2):919.

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