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ML-210

Name: ML-210
Brand: TargetMol
SKU: T8375
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8375Cas No. 1360705-96-9

Alias CID 49766530

ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis.

ML-210

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Purity: 99.03%

Catalog No. T8375Alias CID 49766530Cas No. 1360705-96-9

ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$79	In Stock	In Stock
10 mg	$143	In Stock	In Stock
25 mg	$259	In Stock	In Stock
50 mg	$436	In Stock	In Stock
100 mg	$587	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.03%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis.
Targets&IC50	GPX4:30 nM(EC50)
In vitro	METHODS: Human lung adenocarcinoma cell line HCC4006 was treated with ML-210 (10 µM) for 1 h. CETSA profiles were detected by Western Blot. RESULTS: ML-210 affects the thermal stability of GPX4, consistent with the binding to the cellular target. [1] METHODS: DRD cell lines were treated with ML-210 for 48 h, and cell viability was measured. RESULTS: ML-210 has an IC50 of 107 nM in the DRD cell line. [2]
Synonyms	CID 49766530

Chemical Properties

Molecular Weight	475.32
Formula	C₂₂H₂₀Cl₂N₄O₄
Cas No.	1360705-96-9
Smiles	Cc1onc(C(=O)N2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1[N+]([O-])=O
Relative Density.	1.415 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.63 mg/mL (58.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.1 mg/mL (2.31 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1038 mL	10.5192 mL	21.0385 mL	105.1923 mL
5 mM	0.4208 mL	2.1038 mL	4.2077 mL	21.0385 mL
10 mM	0.2104 mL	1.0519 mL	2.1038 mL	10.5192 mL
20 mM	0.1052 mL	0.5260 mL	1.0519 mL	5.2596 mL
50 mM	0.0421 mL	0.2104 mL	0.4208 mL	2.1038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc