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Catalog No. T8375   CAS 1360705-96-9
Synonyms: CID 49766530

ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity

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ML-210 Chemical Structure
ML-210, CAS 1360705-96-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 79.00
10 mg In stock $ 143.00
25 mg In stock $ 259.00
50 mg In stock $ 437.00
100 mg In stock $ 629.00
200 mg In stock $ 892.00
500 mg In stock $ 1,320.00
1 mL * 10 mM (in DMSO) In stock $ 83.00
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Purity: 97%
Purity: 96.7%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
Targets&IC50 GPX4:30 nM(EC50)
In vitro ML210,the most potent and selective of these, displayed nanomolar potency in the primary screening cell line while maintaining selectivity similar to previously identified probes.?ML210 be highly useful in identifying pathways that can potentially be used for selectively inhibiting cancer cells[1].
Synonyms CID 49766530
Molecular Weight 475.32
Formula C22H20Cl2N4O4
CAS No. 1360705-96-9


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (23.14 mM)

TargetMolReferences and Literature

1. Bittker JA, Weiwer M, Lewis T,et al. Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2[J]. 2010. 2. Weïwer M, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. 3. John K. Eaton, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. Biorxiv. 2018.


1. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15. 2. Bi G, Liang J, Shan G, et al.Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells.Cancer Research.2023: CAN-22-3977.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Colorectal Cancer Compound Library Metabolism Compound Library Oxidation-Reduction Compound Library Anti-Liver Cancer Compound Library Bioactive Compound Library Covalent Inhibitor Library HIF-1 Signaling Pathway Compound Library Cell Cycle Compound Library Anti-Aging Compound Library Reprogramming Compound Library

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NC-R17 Lepadin E Moracin N Glutathione Peroxidase GPX4-IN-4 N-Acetyl lysyltyrosylcysteine amide acetate Ezatiostat hydrochloride Cefdinir

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ML-210 1360705-96-9 Apoptosis GPCR/G Protein MAPK Metabolism oxidation-reduction Glutathione Peroxidase GPX Ferroptosis Ras residue inhibit peroxidase ML210 Covalent selenocysteine glutathione CID 49766530 CID-49766530 Inhibitor CID49766530 ML 210 GPX4 anti-cancer inhibitor