Home Tools

Cart

Losigamone

Catalog No. T27845 CAS 112856-44-7

Synonyms: ADD-137022, AO33, AO 33, ADD 137022, AO-33, ADD137022;Losigamone

Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Losigamone, CAS 112856-44-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 75.00
5 mg	In stock	$ 179.00
10 mg	In stock	$ 270.00
25 mg	In stock	$ 506.00
50 mg	In stock	$ 680.00
100 mg	In stock	$ 990.00

Bulk Inquiry

Select Batch

Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.

In vivo

Losigamone (AO-33) was tested in 52 healthy male volunteers in 4 placebo-controlled phase I studies. In the study 1 single dose of 100, 200, 300, 500, 700, and 1,000 mg losigamone was given as a fast-releasing capsule to 12 subjects. The pharmacokinetics of losigamone measured after administration of 100, 300, and 700 mg was linear. Clearance and t1/2 were about 350 ml/min and 4 h, respectively, the Cmax values of 0.7, 1.7, and 4.4 micrograms/ml were reached after 2.5 h. In study, 2,500 mg losigamone was given as a fast-release capsule for 6 days (t.i.d.) to 12 subjects. There was a small but statistically significant decrease for the AUC but no change in t1/2, Cmax, or tmax comparing single dose kinetics on days 1 and 8. There appeared to be no change in caffeine clearance on days 1 and 9. Study 2 was repeated in 20 volunteers with a film-coated tablet. Pharmacokinetic parameters appeared to be unaffected by this change in galenical formulation. In the study 4 daily doses of 400, 1,200, and 1,800 mg losigamone were given 28 days to 24 subjects. The kinetics of caffeine and antipyrine were compared on days 1 and 29. With the exception of t1/2 for antipyrine in the 400 mg group there was no statistically significant change in pharmacokinetic parameters. Generally, losigamone was well tolerated and no serious adverse side effects occurred. In some subjects, a reversible increase in transaminases was observed.[1]

Synonyms	ADD-137022, AO33, AO 33, ADD 137022, AO-33, ADD137022;Losigamone
Molecular Weight	254.67
Formula	C12H11ClO4
CAS No.	112856-44-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Biber A, et al. Pharmacokinetics of losigamone, a new antiepileptic drug, in healthy male volunteers. Int J Clin Pharmacol Ther. 1996;34(1):6-11. 2. Xiao Y, et al. Losigamone add-on therapy for partial epilepsy. Cochrane Database Syst Rev. 2012;(6):CD009324. 3. Dimpfel W, et al. Effects of the anticonvulsant losigamone and its isomers on the GABAA receptor system. Epilepsia. 1995;36(10):983-989. 4. Gebhardt C, et al. The antiepileptic drug losigamone decreases the persistent Na+ current in rat hippocampal neurons. Brain Res. 2001;920(1-2):27-31. 5. Xiao Y, et al. Losigamone add-on therapy for partial epilepsy. Cochrane Database Syst Rev. 2015;(12):CD009324.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Neurotransmitter Receptor Compound Library

Related Products

Related compounds with same targets

(E)-GABAB receptor antagonist 1 Flumazenil Saclofen Ginsenoside Rc (-)-Bicuculline methochloride RO 4938581 2'MeO6MF (R)-Baclofen hydrochloride

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Losigamone 112856-44-7 Membrane transporter/Ion channel Neuroscience GABA Receptor ADD-137022 ADD137022 AO33 AO 33 ADD 137022 AO-33 ADD137022;Losigamone inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.