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Metabolism FXR Lithocholic acid

Lithocholic acid

Catalog No. T2202   CAS 434-13-9
Synonyms: 3α-Hydroxy-5β-cholanic acid

Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.

Lithocholic acid, CAS 434-13-9
Pack Size Availability Price/USD Quantity
5 mg In stock 16.00
10 mg In stock 20.00
25 mg In stock 30.00
50 mg In stock 38.00
100 mg In stock 43.00
200 mg In stock 50.00
500 mg In stock 60.00
1 g In stock 75.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
Targets&IC50 FXR,   PXR,   VD,  
Kinase Assay Competitive ligand binding assay.: Ligand binding is performed using lysates from COS-7 cells transfected with expression plasmids for VDR or RXRα. Binding is performed overnight at 4°C in lysate buffer with 0.71 nM (18 Ci/mmol) [3H]1,25(OH)2D3 and bile acid competitor. Unbound [3H]1,25(OH)2D3 is removed by adsorption to dextran-coated charcoal and the supernatant removed for scintillation counting. Ki values are calculated from a computer fit of competition curves from triplicate assays.
Animal Research
Animal Model: Mouse
Synonyms 3α-Hydroxy-5β-cholanic acid
Purity 99.69%
Molecular Weight 376.58
Formula C24H40O3
CAS No. 434-13-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 70 mg/mL (185.9 mM)

Ethanol: 44 mg/mL (116.8 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Staudinger JL, et al. PNAS, 2001, 98(6), 3369-3374. 2. Parks DJ, et al. Science, 1999, 284(5418), 1365-1368. 3. Makishima M, et al. Science, 2002, 296(5571), 1313-1316. 4. Ogawa A, et al. Jpn J Cancer Res, 1998, 89(11), 1154-1159. 5. Kozoni V, et al. Carcinogenesis, 2000, 21(5), 999-1005. 6. Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Autophagy Compound Library Human Endogenous Metabolite Compound Library FDA-approved Drug Library Bioactive Lipid Compound Library Anti-Metabolism Disease Compound Library

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