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Lisinopril dihydrate

Catalog No. T0706 CAS 83915-83-7

Synonyms: Lisinopril, Renacor, MK-521 (dihydrate)

Lisinopril dihydrate （MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

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Lisinopril dihydrate, CAS 83915-83-7

Pack Size	Availability	Price/USD
500 mg	In stock	$ 57.00
1 g	In stock	$ 91.00
1 mL * 10 mM (in H2O)	In stock	$ 74.00

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Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lisinopril dihydrate （MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
In vitro	Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. [1] Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. Lisinopril inhibits Angiotensin-converting enzyme (ACE) in vitro, as well as after parenteral and oral administration to humans; its oral bioavailability is only 25-29%, but it has a longer duration of action than enalapril. [2]
In vivo	Lisinopril treated SHR rats has significantly raised total cholesterol levels compared to untreated spontaneously hypertensive rats (SHR) rats (+27%), but not compared to lisinopril treated Wistar Kyoto rats (WKY) rats. [3] Lisinopril is a long-acting angiotensin-converting enzyme inhibitor which blocks the renin-angiotensin system (RAS) and reduces systemic blood pressure in rats. Lisinopril reduces the hydroxyproline level and inhibits accumulation of collagens in the pulmonary tissue of the treatment group (paraquat + lisinopril) and per-treatment group (lisinopril + paraquat) in rats. [4] Lisinopril results in preserved ultrafiltration volume (UF), glucose reabsorption (D 1 /D 0 glucose) and peritoneal thickness in rats. [5] Lisinopril (0.2 mg/kg twice a day for 10 days) protects the cell membrane integrity and lessens free radical-induced oxidant stress in guinea pig hearts. [6]

Synonyms	Lisinopril, Renacor, MK-521 (dihydrate)
Molecular Weight	441.52
Formula	C21H35N3O7
CAS No.	83915-83-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

References and Literature

1. Nemoto S, et al. J Am Coll Cardiol,2002, 40(1), 149-154. 2. Swaan PW, et al. Biochim Biophys Acta,1995, 1236(1), 31-38. 3. Mantle D, et al. Clin Chim Acta, 2000, 299(1-2), 1-10. 4. Mohammadi-Karakani A, et al. Clin Chim Acta,2006, 367(1-2), 170-174. 5. Duman S, et al. Int J Artif Organs,2005, 28(2), 156-163.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Immunology/Inflammation Compound Library Clinical Compound Library Preclinical Compound Library FDA-Approved & Pharmacopeia Drug Library Endocrinology-Hormone Compound Library Nonsteroidal Anti-Inflammatory Compound Library

Related Products

Related compounds with same targets

Alacepril Phosphoramidon Disodium Valsartan Losartan (Sar¹)-Angiotensin II acetate Remodelin hydrobromide Resorcinolnaphthalein Sparsentan

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Keywords

Lisinopril dihydrate 83915-83-7 Endocrinology/Hormones Immunology/Inflammation RAAS MRP Inhibitor inhibit Lisinopril MK521 Angiotensin-converting Enzyme (ACE) MK-521 dihydrate Renacor MK-521 Lisinopril Dihydrate MK 521 MK-521 (dihydrate) inhibitor

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