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Linsidomine hydrochloride

Catalog No. T23356 CAS 16142-27-1

Synonyms: SIN-1 chloride

Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release.

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Linsidomine hydrochloride Chemical Structure

Linsidomine hydrochloride, CAS 16142-27-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 176.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 99.81%

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Storage & Solubility Information

Description	Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release.
In vitro	SIN-1 decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion [1][2].
In vivo	SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits a potent vasorelaxant effect and inhibition of platelet aggregation.[1] SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.[2]

Synonyms	SIN-1 chloride
Molecular Weight	206.63
Formula	C6H11ClN4O2
CAS No.	16142-27-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (108.9 mM), Sonication and heating to 60℃ are recommended.

H2O: 45.0 mg/mL (217.8 mM), Sonication is recommended.

References and Literature

1. Nishikawa M, et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther. 1982;220(1):183-190. 2. Siegfried MR, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992;260(2):668-675.

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This product is contained In the following compound libraries：

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Keywords

Linsidomine hydrochloride 16142-27-1 Others SIN 1 Chloride SIN-1 Chloride SIN-1 chloride SIN1 Chloride Linsidomine Hydrochloride inhibitor inhibit

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