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Lefradafiban

Catalog No. T27808 CAS 149503-79-7

Synonyms: BIBU 104, BIBU104, BIBU-104

Lefradafiban（BIBU-104） is an oral platelet glycoprotein IIb/IIIa receptor antagonist for the study of angina pectoris and acute coronary syndromes.

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Lefradafiban, CAS 149503-79-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 342.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,150.00
25 mg	In stock	$ 1,680.00
50 mg	In stock	$ 2,290.00

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Purity: 98.37%

ee: 97.87%

Purity: 97.71%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lefradafiban（BIBU-104） is an oral platelet glycoprotein IIb/IIIa receptor antagonist for the study of angina pectoris and acute coronary syndromes.
In vivo	Lefradafiban (30, 45, and 60 mg; oral; three times daily for 48 hours; patients with stable angina undergoing angioplasty) is an effective oral glycoprotein IIb/IIIa receptor blocker.[1]

Synonyms	BIBU 104, BIBU104, BIBU-104
Molecular Weight	439.46
Formula	C23H25N3O6
CAS No.	149503-79-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (102.4 mM)

References and Literature

1. Akkerhuis KM, et al. Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty. Heart. 2001 Apr;85(4):444-50. 2. Akkerhuis KM, et al. Fibrinogen Receptor Occupancy Study (FROST) Investigators. Safety and preliminary efficacy of one month glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation; a phase II study. Eur Heart J. 2000 Dec;21(24):2042-55. 3. Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8. 4. Drewe J, et al. Absorption of lefradafiban from different sites of the gastrointestinal tract. Br J Clin Pharmacol. 2000 Jul;50(1):69-72.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lefradafiban 149503-79-7 Others BIBU 104 BIBU104 BIBU-104 inhibitor inhibit

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