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LP-533401

Catalog No. T15778 CAS 945976-43-2

LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.

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LP-533401, CAS 945976-43-2

Pack Size	Availability	Price/USD
5 mg	35 days	$ 770.00
10 mg	35 days	$ 1,360.00
25 mg	35 days	$ 2,970.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
In vitro	At a dose of 1 μM, LP-533401 fully suppresses serotonin production in Tph1–expressing cells [1].
In vivo	Mice treated repeatedly with LP-533401 (30–250 mg/kg per day) exhibit marked 5-HT content reductions in the gut, lungs, and blood, but not in the brain. Adult, healthy mice treated with the Tph-1 inhibitor LP-533401 display a 30% decrease in circulating serotonin levels, with a consequent 30% increase in osteoblast numbers. Pharmacokinetic studies in rodents show that the LP-533401 level in the brain is negligible following oral administration, indicating that it is virtually unable to cross the blood-brain barrier[1]. Lung and gut 5-HT contents decrease by 50%, after a single LP533401 dose (250 mg/kg), whereas blood 5-HT levels remain unchanged, suggesting gut and lung 5-HT synthesis[2]. Administration of LP533401 to mice injected with EL4 cells inhibits the decrement in osteoblast numbers and trabecular bone volume prolongs survial, and decreases leukemic infiltration[3].

Molecular Weight	526.48
Formula	C27H22F4N4O3
CAS No.	945976-43-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yadav, V.K., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16(3), 308-312 (2010). 2. Abid S, et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L500-8. 3. Krevvata M, et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood. 2014 Oct 30;124(18):2834-46.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LP-533401 945976-43-2 Metabolism Hydroxylase LP533401 LP 533401 inhibitor inhibit

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