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Catalog No. T7303   CAS 168079-32-1
Synonyms: WAY-VPA 985, VPA-985

Lixivaptan is an orally active and selective <a href="/target/Vasopressin_Receptor" style="display: inline; color: #c13a36">Vasopressin Receptor</a> V2 antagonist(Ki = 2.3 nM)

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LIXIVAPTAN, CAS 168079-32-1
Pack Size Availability Price/USD Quantity
2 mg In stock $ 54.00
5 mg In stock $ 77.00
10 mg In stock $ 131.00
25 mg In stock $ 262.00
50 mg In stock $ 446.00
100 mg In stock $ 759.00
1 mL * 10 mM (in DMSO) In stock $ 86.00
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Purity: 99.33%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Lixivaptan is an orally active and selective vasopressin receptor V2 antagonist(Ki = 2.3 nM)
Targets&IC50 rat V2:2.3 nM (IC50), human V2:1.2 nM (IC50)
In vivo Consistent with the development of a polycystic kidney phenotype, control PCK rats showed enlarged kidneys, extensive cyst formation, and early signs of serum creatinine elevation at 12 weeks of age.?Compared to controls, PCK rats treated with low-dose lixivaptan showed a 26% reduction in % kidney weight/body weight (p < 0.01);?a 54% reduction in kidney cystic score (p < 0.001), a histomorphometric measure of cystic burden;?a 23% reduction in kidney cAMP levels (p < 0.05), a biochemical marker of disease;?and a 13% reduction in plasma creatinine (p < 0.001), indicating preserved renal function.?These reductions were associated with 3-fold increases in 24-h urine output, demonstrating the potent aquaretic effect of lixivaptan[1].
Animal Research Four-week old PCK rats were fed rodent chow with 0.5% lixivaptan (low dose) or 1% lixivaptan (high dose), or chow only (control) for 8 weeks.?Urine output was measured at weeks 7 and 10 of age.?Animals were killed at 12 weeks of age;?kidneys and livers were collected, weighted, and analyzed for cyclic adenosine 3',5'-monophosphate (cAMP) levels and cystic burden and fibrosis;?serum creatinine and sodium were measured[1].
Synonyms WAY-VPA 985, VPA-985
Molecular Weight 473.93
Formula C27H21ClFN3O2
CAS No. 168079-32-1


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 150 mg/mL (316.50 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang X, Constans MM, Chebib FT.et al.Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model[J].Am J Nephrol. 2019;49(6):487-493. 2. Di Mise A, Venneri M, Ranieri M.et al.Lixivaptan, a New Generation Diuretic, Counteracts Vasopressin-Induced Aquaporin-2 Trafficking and Function in Renal Collecting Duct Cells.Int J Mol Sci. 2019 Dec 26;21(1).

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Human Metabolite Library Inhibitor Library Neuronal Signaling Compound Library Clinical Compound Library Preclinical Compound Library Bioactive Compounds Library Max ReFRAME Related Library NO PAINS Compound Library Drug Repurposing Compound Library

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d[Leu4,Lys8]-VP acetate Argipressin LIXIVAPTAN Mozavaptan Desmopressin acetate (16679-58-6 free base) Desmopressin Atosiban Fuscoside

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LIXIVAPTAN 168079-32-1 GPCR/G Protein Vasopressin Receptor VPA 985 VPA985 inhibit WAY-VPA 985 Inhibitor VPA-985 inhibitor