Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KRN5 is an effective inhibitor of NFAT5 with an IC50 of 750 nM and can be used in studies about chronic arthritis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 970.00 | |
25 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 1,158.00 |
Description | KRN5 is an effective inhibitor of NFAT5 with an IC50 of 750 nM and can be used in studies about chronic arthritis. |
Targets&IC50 | NFAT5:750 nM |
In vitro | KRN5 (1 μM) inhibits the expressions of NFAT5, IL-6,MCP-1, and GM-CSF in RAW264.7 macrophages stimulated with LPS[1]. |
In vivo | In DBA/1Jmice immunized with bovine type II collagen, KRN5 (15 and 60 mg/kg; oral) dose-dependently mitigates arthritis severity. KRN5 significantly decreases the concentration of serum anti-type II collagen IgG in the sera. KRN5 lowers TNF-α and IL-6 production by LPS-stimulated splenocytes in mice[1]. |
Molecular Weight | 459.47 |
Formula | C27H22FNO5 |
CAS No. | 1800465-47-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (10.9 mM), Sonication and heating to 80℃ are recommended.
You can also refer to dose conversion for different animals. More
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KRN5 1800465-47-7 Others KRN-5 KRN 5 inhibitor inhibit